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SMILES: CN1CCN(CC1)c1cccc(Nc2ncc3[nH]c(cc3n2)-c2ccsc2)c1

InChI Key: InChIKey=KZSALPUISKJCNC-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 372158   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM372158 (N-(3-(4- methylpiperazin-1- yl)phenyl)-6- (thiophe...) Show SMILES CN1CCN(CC1)c1cccc(Nc2ncc3[nH]c(cc3n2)-c2ccsc2)c1 Show InChI InChI=1S/C21H22N6S/c1-26-6-8-27(9-7-26)17-4-2-3-16(11-17)23-21-22-13-20-19(25-21)12-18(24-20)15-5-10-28-14-15/h2-5,10-14,24H,6-9H2,1H3,(H,22,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY HEALTH NETWORK US Patent					Assay Description Active RIPK2 was purchased from Life Technologies as His-tagged of catalytic domain (amin acids 1-299) of human RIPK2 kinase expressed in insect cell...				US Patent US10875863 (2020)
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM372158 (N-(3-(4- methylpiperazin-1- yl)phenyl)-6- (thiophe...) Show SMILES CN1CCN(CC1)c1cccc(Nc2ncc3[nH]c(cc3n2)-c2ccsc2)c1 Show InChI InChI=1S/C21H22N6S/c1-26-6-8-27(9-7-26)17-4-2-3-16(11-17)23-21-22-13-20-19(25-21)12-18(24-20)15-5-10-28-14-15/h2-5,10-14,24H,6-9H2,1H3,(H,22,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
National Taiwan University					Assay Description RIPK2 activity was measured using an indirect ELISA detection system. His—RIPK2 (0.6 nM) was incubated in the presence of 6 μM ATP (Sigma cat # ...				J Med Chem 51: 2795-806 (2008) BindingDB Entry DOI: 10.7270/Q289186K
					More data for this Ligand-Target Pair