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SMILES: Cc1ccccc1-c1cc2nc(Nc3ccc(CN4CCOCC4)cc3)ncc2[nH]1

InChI Key: InChIKey=ONSCGBZIDKPAFU-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 372162   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM372162
PNG
(N-(4- (morpholino- methyl) phenyl)-6-(o-tolyl)- 5H...)
Show SMILES Cc1ccccc1-c1cc2nc(Nc3ccc(CN4CCOCC4)cc3)ncc2[nH]1
Show InChI InChI=1S/C24H25N5O/c1-17-4-2-3-5-20(17)21-14-22-23(27-21)15-25-24(28-22)26-19-8-6-18(7-9-19)16-29-10-12-30-13-11-29/h2-9,14-15,27H,10-13,16H2,1H3,(H,25,26,28)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



UNIVERSITY HEALTH NETWORK

US Patent


Assay Description
Active RIPK2 was purchased from Life Technologies as His-tagged of catalytic domain (amin acids 1-299) of human RIPK2 kinase expressed in insect cell...


US Patent US10875863 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM372162
PNG
(N-(4- (morpholino- methyl) phenyl)-6-(o-tolyl)- 5H...)
Show SMILES Cc1ccccc1-c1cc2nc(Nc3ccc(CN4CCOCC4)cc3)ncc2[nH]1
Show InChI InChI=1S/C24H25N5O/c1-17-4-2-3-5-20(17)21-14-22-23(27-21)15-25-24(28-22)26-19-8-6-18(7-9-19)16-29-10-12-30-13-11-29/h2-9,14-15,27H,10-13,16H2,1H3,(H,25,26,28)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



National Taiwan University



Assay Description
RIPK2 activity was measured using an indirect ELISA detection system. His—RIPK2 (0.6 nM) was incubated in the presence of 6 μM ATP (Sigma cat # ...


J Med Chem 51: 2795-806 (2008)


BindingDB Entry DOI: 10.7270/Q289186K
More data for this
Ligand-Target Pair