null

SMILES: CN1CCN(Cc2ccc(Nc3ncc4[nH]c(cc4n3)-c3ccccc3C)cc2)CC1

InChI Key: InChIKey=NUZZWDDXIBCLOL-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 372165   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM372165 (N-(4-((4- methylpiperazin-1- yl)methyl)phenyl)- 6-...) Show SMILES CN1CCN(Cc2ccc(Nc3ncc4[nH]c(cc4n3)-c3ccccc3C)cc2)CC1 Show InChI InChI=1S/C25H28N6/c1-18-5-3-4-6-21(18)22-15-23-24(28-22)16-26-25(29-23)27-20-9-7-19(8-10-20)17-31-13-11-30(2)12-14-31/h3-10,15-16,28H,11-14,17H2,1-2H3,(H,26,27,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY HEALTH NETWORK US Patent					Assay Description Active RIPK2 was purchased from Life Technologies as His-tagged of catalytic domain (amin acids 1-299) of human RIPK2 kinase expressed in insect cell...				US Patent US10875863 (2020)
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM372165 (N-(4-((4- methylpiperazin-1- yl)methyl)phenyl)- 6-...) Show SMILES CN1CCN(Cc2ccc(Nc3ncc4[nH]c(cc4n3)-c3ccccc3C)cc2)CC1 Show InChI InChI=1S/C25H28N6/c1-18-5-3-4-6-21(18)22-15-23-24(28-22)16-26-25(29-23)27-20-9-7-19(8-10-20)17-31-13-11-30(2)12-14-31/h3-10,15-16,28H,11-14,17H2,1-2H3,(H,26,27,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
National Taiwan University					Assay Description RIPK2 activity was measured using an indirect ELISA detection system. His—RIPK2 (0.6 nM) was incubated in the presence of 6 μM ATP (Sigma cat # ...				J Med Chem 51: 2795-806 (2008) BindingDB Entry DOI: 10.7270/Q289186K
					More data for this Ligand-Target Pair