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SMILES: Fc1c(Cl)cc(cc1-c1ccnc(c1)-n1cccn1)C#N

InChI Key: InChIKey=JEAROKHPOGFPGH-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 372970   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM372970 (3-chloro-4-fluoro-5-[2- | US10246432, Example 11 |...) Show SMILES Fc1c(Cl)cc(cc1-c1ccnc(c1)-n1cccn1)C#N Show InChI InChI=1S/C15H8ClFN4/c16-13-7-10(9-18)6-12(15(13)17)11-2-4-19-14(8-11)21-5-1-3-20-21/h1-8H	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	6.92	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Heptares Therapeutics Limited US Patent					Assay Description Membrane PreparationcDNA encoding the human mGlu5 receptor was transfected into HEK293 cells using the transfection reagent Genejuice (Novagen). Fort...				US Patent US10584111 (2020) BindingDB Entry DOI: 10.7270/Q2BR8VK9
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM372970 (3-chloro-4-fluoro-5-[2- | US10246432, Example 11 |...) Show SMILES Fc1c(Cl)cc(cc1-c1ccnc(c1)-n1cccn1)C#N Show InChI InChI=1S/C15H8ClFN4/c16-13-7-10(9-18)6-12(15(13)17)11-2-4-19-14(8-11)21-5-1-3-20-21/h1-8H	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	6.92	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2ZS2ZVS
					More data for this Ligand-Target Pair