BDBM373765 (S)-3-chloro-4-((1-(3-chloro-2-fluorobenzyl)pyrrolidin-3-yl)(methyl)amino)-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide::US10246453, Example 32::US10815229, Example 32

SMILES: CN([C@H]1CCN(Cc2cccc(Cl)c2F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1

InChI Key: InChIKey=KUQDSRILSXRRIC-AWEZNQCLSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 373765   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373765 ((S)-3-chloro-4-((1-(3-chloro-2-fluorobenzyl)pyrrol...) Show SMILES CN([C@H]1CCN(Cc2cccc(Cl)c2F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1 |r| Show InChI InChI=1S/C20H20Cl2FN5O2S2/c1-27(14-7-8-28(11-14)10-13-3-2-4-16(21)19(13)23)18-6-5-15(9-17(18)22)32(29,30)26-20-24-12-25-31-20/h2-6,9,12,14H,7-8,10-11H2,1H3,(H,24,25,26)/t14-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM373765 ((S)-3-chloro-4-((1-(3-chloro-2-fluorobenzyl)pyrrol...) Show SMILES CN([C@H]1CCN(Cc2cccc(Cl)c2F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1 |r| Show InChI InChI=1S/C20H20Cl2FN5O2S2/c1-27(14-7-8-28(11-14)10-13-3-2-4-16(21)19(13)23)18-6-5-15(9-17(18)22)32(29,30)26-20-24-12-25-31-20/h2-6,9,12,14H,7-8,10-11H2,1H3,(H,24,25,26)/t14-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.41E+3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair
Sodium channel alpha subunit (Homo sapiens (Human))	BDBM373765 ((S)-3-chloro-4-((1-(3-chloro-2-fluorobenzyl)pyrrol...) Show SMILES CN([C@H]1CCN(Cc2cccc(Cl)c2F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1 |r| Show InChI InChI=1S/C20H20Cl2FN5O2S2/c1-27(14-7-8-28(11-14)10-13-3-2-4-16(21)19(13)23)18-6-5-15(9-17(18)22)32(29,30)26-20-24-12-25-31-20/h2-6,9,12,14H,7-8,10-11H2,1H3,(H,24,25,26)/t14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...				US Patent US10815229 (2020)
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373765 ((S)-3-chloro-4-((1-(3-chloro-2-fluorobenzyl)pyrrol...) Show SMILES CN([C@H]1CCN(Cc2cccc(Cl)c2F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1 |r| Show InChI InChI=1S/C20H20Cl2FN5O2S2/c1-27(14-7-8-28(11-14)10-13-3-2-4-16(21)19(13)23)18-6-5-15(9-17(18)22)32(29,30)26-20-24-12-25-31-20/h2-6,9,12,14H,7-8,10-11H2,1H3,(H,24,25,26)/t14-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...				US Patent US10815229 (2020)
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM373765 ((S)-3-chloro-4-((1-(3-chloro-2-fluorobenzyl)pyrrol...) Show SMILES CN([C@H]1CCN(Cc2cccc(Cl)c2F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1 |r| Show InChI InChI=1S/C20H20Cl2FN5O2S2/c1-27(14-7-8-28(11-14)10-13-3-2-4-16(21)19(13)23)18-6-5-15(9-17(18)22)32(29,30)26-20-24-12-25-31-20/h2-6,9,12,14H,7-8,10-11H2,1H3,(H,24,25,26)/t14-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.41E+3	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...				US Patent US10815229 (2020)
					More data for this Ligand-Target Pair
Sodium channel alpha subunit (Homo sapiens (Human))	BDBM373765 ((S)-3-chloro-4-((1-(3-chloro-2-fluorobenzyl)pyrrol...) Show SMILES CN([C@H]1CCN(Cc2cccc(Cl)c2F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1 |r| Show InChI InChI=1S/C20H20Cl2FN5O2S2/c1-27(14-7-8-28(11-14)10-13-3-2-4-16(21)19(13)23)18-6-5-15(9-17(18)22)32(29,30)26-20-24-12-25-31-20/h2-6,9,12,14H,7-8,10-11H2,1H3,(H,24,25,26)/t14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair