BDBM373807 4-((trans-1-benzyl-4-methylpyrrolidin-3-yl)amino)-3-chloro-N-(thiazol-2-yl)benzenesulfonamide::US10246453, Example 74

SMILES: C[C@H]1CN(Cc2ccccc2)CC1Nc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1

InChI Key: InChIKey=TXCKAMAKLHVARQ-OOJLDXBWSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 373807   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373807 (4-((trans-1-benzyl-4-methylpyrrolidin-3-yl)amino)-...) Show SMILES C[C@H]1CN(Cc2ccccc2)CC1Nc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1 |r| Show InChI InChI=1S/C21H23ClN4O2S2/c1-15-12-26(13-16-5-3-2-4-6-16)14-20(15)24-19-8-7-17(11-18(19)22)30(27,28)25-21-23-9-10-29-21/h2-11,15,20,24H,12-14H2,1H3,(H,23,25)/t15-,20?/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	167	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM373807 (4-((trans-1-benzyl-4-methylpyrrolidin-3-yl)amino)-...) Show SMILES C[C@H]1CN(Cc2ccccc2)CC1Nc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1 |r| Show InChI InChI=1S/C21H23ClN4O2S2/c1-15-12-26(13-16-5-3-2-4-6-16)14-20(15)24-19-8-7-17(11-18(19)22)30(27,28)25-21-23-9-10-29-21/h2-11,15,20,24H,12-14H2,1H3,(H,23,25)/t15-,20?/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.67E+3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair
Sodium channel alpha subunit (Homo sapiens (Human))	BDBM373807 (4-((trans-1-benzyl-4-methylpyrrolidin-3-yl)amino)-...) Show SMILES C[C@H]1CN(Cc2ccccc2)CC1Nc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1 |r| Show InChI InChI=1S/C21H23ClN4O2S2/c1-15-12-26(13-16-5-3-2-4-6-16)14-20(15)24-19-8-7-17(11-18(19)22)30(27,28)25-21-23-9-10-29-21/h2-11,15,20,24H,12-14H2,1H3,(H,23,25)/t15-,20?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373807 (4-((trans-1-benzyl-4-methylpyrrolidin-3-yl)amino)-...) Show SMILES C[C@H]1CN(Cc2ccccc2)CC1Nc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1 |r| Show InChI InChI=1S/C21H23ClN4O2S2/c1-15-12-26(13-16-5-3-2-4-6-16)14-20(15)24-19-8-7-17(11-18(19)22)30(27,28)25-21-23-9-10-29-21/h2-11,15,20,24H,12-14H2,1H3,(H,23,25)/t15-,20?/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair
Sodium channel alpha subunit (Homo sapiens (Human))	BDBM373807 (4-((trans-1-benzyl-4-methylpyrrolidin-3-yl)amino)-...) Show SMILES C[C@H]1CN(Cc2ccccc2)CC1Nc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1 |r| Show InChI InChI=1S/C21H23ClN4O2S2/c1-15-12-26(13-16-5-3-2-4-6-16)14-20(15)24-19-8-7-17(11-18(19)22)30(27,28)25-21-23-9-10-29-21/h2-11,15,20,24H,12-14H2,1H3,(H,23,25)/t15-,20?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.54E+3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair