BDBM373871 (S)-4-((1-((2-cyclopropylthiazol-4-yl)methyl)pyrrolidin-3-yl)(methyl)amino)-2-fluoro-5-methyl-N-(thiazol-4-yl)benzenesulfonamide::US10246453, Example 138::US10815229, Example 138

SMILES: CN([C@H]1CCN(Cc2csc(n2)C2CC2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1

InChI Key: InChIKey=WRTJMOLVYYCZSD-KRWDZBQOSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 373871   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373871 ((S)-4-((1-((2-cyclopropylthiazol-4-yl)methyl)pyrro...) Show SMILES CN([C@H]1CCN(Cc2csc(n2)C2CC2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1 Show InChI InChI=1S/C22H26FN5O2S3/c1-14-7-20(33(29,30)26-21-12-31-13-24-21)18(23)8-19(14)27(2)17-5-6-28(10-17)9-16-11-32-22(25-16)15-3-4-15/h7-8,11-13,15,17,26H,3-6,9-10H2,1-2H3/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM373871 ((S)-4-((1-((2-cyclopropylthiazol-4-yl)methyl)pyrro...) Show SMILES CN([C@H]1CCN(Cc2csc(n2)C2CC2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1 Show InChI InChI=1S/C22H26FN5O2S3/c1-14-7-20(33(29,30)26-21-12-31-13-24-21)18(23)8-19(14)27(2)17-5-6-28(10-17)9-16-11-32-22(25-16)15-3-4-15/h7-8,11-13,15,17,26H,3-6,9-10H2,1-2H3/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair
Sodium channel alpha subunit (Homo sapiens (Human))	BDBM373871 ((S)-4-((1-((2-cyclopropylthiazol-4-yl)methyl)pyrro...) Show SMILES CN([C@H]1CCN(Cc2csc(n2)C2CC2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1 Show InChI InChI=1S/C22H26FN5O2S3/c1-14-7-20(33(29,30)26-21-12-31-13-24-21)18(23)8-19(14)27(2)17-5-6-28(10-17)9-16-11-32-22(25-16)15-3-4-15/h7-8,11-13,15,17,26H,3-6,9-10H2,1-2H3/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.48E+3	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...				US Patent US10815229 (2020)
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373871 ((S)-4-((1-((2-cyclopropylthiazol-4-yl)methyl)pyrro...) Show SMILES CN([C@H]1CCN(Cc2csc(n2)C2CC2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1 Show InChI InChI=1S/C22H26FN5O2S3/c1-14-7-20(33(29,30)26-21-12-31-13-24-21)18(23)8-19(14)27(2)17-5-6-28(10-17)9-16-11-32-22(25-16)15-3-4-15/h7-8,11-13,15,17,26H,3-6,9-10H2,1-2H3/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...				US Patent US10815229 (2020)
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM373871 ((S)-4-((1-((2-cyclopropylthiazol-4-yl)methyl)pyrro...) Show SMILES CN([C@H]1CCN(Cc2csc(n2)C2CC2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1 Show InChI InChI=1S/C22H26FN5O2S3/c1-14-7-20(33(29,30)26-21-12-31-13-24-21)18(23)8-19(14)27(2)17-5-6-28(10-17)9-16-11-32-22(25-16)15-3-4-15/h7-8,11-13,15,17,26H,3-6,9-10H2,1-2H3/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...				US Patent US10815229 (2020)
					More data for this Ligand-Target Pair
Sodium channel alpha subunit (Homo sapiens (Human))	BDBM373871 ((S)-4-((1-((2-cyclopropylthiazol-4-yl)methyl)pyrro...) Show SMILES CN([C@H]1CCN(Cc2csc(n2)C2CC2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1 Show InChI InChI=1S/C22H26FN5O2S3/c1-14-7-20(33(29,30)26-21-12-31-13-24-21)18(23)8-19(14)27(2)17-5-6-28(10-17)9-16-11-32-22(25-16)15-3-4-15/h7-8,11-13,15,17,26H,3-6,9-10H2,1-2H3/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.48E+3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair