BDBM374029 (S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6-difluoro-3-methyl-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide 2,2,2-trifluoroacetate::US10246453, Example 296::US10246453, Example 297::US10662184, Example 296::US10815229, Example 296
SMILES: CN([C@H]1CCN(Cc2cccc(C)n2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1ncns1
InChI Key: InChIKey=BRERACUJOCTFKW-INIZCTEOSA-N
Data: 13 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM374029 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which... | J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM374029 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which... | J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel alpha subunit (Homo sapiens (Human)) | BDBM374029 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which... | J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM374029 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and... | J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM374029 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which... | J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM374029 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which... | J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ep nav1.6 (Homo sapiens (Human)) | BDBM374029 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals Inc. US Patent | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and... | US Patent US10815229 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM374029 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and... | J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 alpha subunit (Homo sapiens (Human)) | BDBM374029 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals Inc. US Patent | Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ... | US Patent US10662184 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM374029 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals Inc. US Patent | Assay Description In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma... | US Patent US10815229 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM374029 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals Inc. US Patent | Assay Description In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma... | US Patent US10815229 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel alpha subunit (Homo sapiens (Human)) | BDBM374029 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals Inc. US Patent | Assay Description In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma... | US Patent US10815229 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel alpha subunit (Homo sapiens (Human)) | BDBM374029 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which... | J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC | |||||||||||
More data for this Ligand-Target Pair |