null

SMILES: C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)c1nccnc1C

InChI Key: InChIKey=UAHUGOMRCGEZOI-UHOSZYNNSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 376818   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM376818 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)c1nccnc1C |r| Show InChI InChI=1S/C28H30FN7O/c1-16-10-18(12-19(30)11-16)21-6-7-31-15-25(21)35-28(37)22-4-5-24(29)23-13-20(14-34-26(22)23)36(3)27-17(2)32-8-9-33-27/h4-9,13-16,18-19H,10-12,30H2,1-3H3,(H,35,37)/t16-,18+,19-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q20G3NF8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM376818 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)c1nccnc1C |r| Show InChI InChI=1S/C28H30FN7O/c1-16-10-18(12-19(30)11-16)21-6-7-31-15-25(21)35-28(37)22-4-5-24(29)23-13-20(14-34-26(22)23)36(3)27-17(2)32-8-9-33-27/h4-9,13-16,18-19H,10-12,30H2,1-3H3,(H,35,37)/t16-,18+,19-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description Pim-2 kinase assay—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q20G3NF8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM376818 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)c1nccnc1C |r| Show InChI InChI=1S/C28H30FN7O/c1-16-10-18(12-19(30)11-16)21-6-7-31-15-25(21)35-28(37)22-4-5-24(29)23-13-20(14-34-26(22)23)36(3)27-17(2)32-8-9-33-27/h4-9,13-16,18-19H,10-12,30H2,1-3H3,(H,35,37)/t16-,18+,19-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q20G3NF8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM376818 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)c1nccnc1C |r| Show InChI InChI=1S/C28H30FN7O/c1-16-10-18(12-19(30)11-16)21-6-7-31-15-25(21)35-28(37)22-4-5-24(29)23-13-20(14-34-26(22)23)36(3)27-17(2)32-8-9-33-27/h4-9,13-16,18-19H,10-12,30H2,1-3H3,(H,35,37)/t16-,18+,19-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 641-62 (2007) BindingDB Entry DOI: 10.7270/Q2MP55J7
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM376818 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)c1nccnc1C |r| Show InChI InChI=1S/C28H30FN7O/c1-16-10-18(12-19(30)11-16)21-6-7-31-15-25(21)35-28(37)22-4-5-24(29)23-13-20(14-34-26(22)23)36(3)27-17(2)32-8-9-33-27/h4-9,13-16,18-19H,10-12,30H2,1-3H3,(H,35,37)/t16-,18+,19-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				Citation and Details BindingDB Entry DOI: 10.7270/Q20V8GZM
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM376818 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)c1nccnc1C |r| Show InChI InChI=1S/C28H30FN7O/c1-16-10-18(12-19(30)11-16)21-6-7-31-15-25(21)35-28(37)22-4-5-24(29)23-13-20(14-34-26(22)23)36(3)27-17(2)32-8-9-33-27/h4-9,13-16,18-19H,10-12,30H2,1-3H3,(H,35,37)/t16-,18+,19-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 641-62 (2007) BindingDB Entry DOI: 10.7270/Q2MP55J7
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM376818 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)c1nccnc1C |r| Show InChI InChI=1S/C28H30FN7O/c1-16-10-18(12-19(30)11-16)21-6-7-31-15-25(21)35-28(37)22-4-5-24(29)23-13-20(14-34-26(22)23)36(3)27-17(2)32-8-9-33-27/h4-9,13-16,18-19H,10-12,30H2,1-3H3,(H,35,37)/t16-,18+,19-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				Citation and Details BindingDB Entry DOI: 10.7270/Q20V8GZM
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM376818 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)c1nccnc1C |r| Show InChI InChI=1S/C28H30FN7O/c1-16-10-18(12-19(30)11-16)21-6-7-31-15-25(21)35-28(37)22-4-5-24(29)23-13-20(14-34-26(22)23)36(3)27-17(2)32-8-9-33-27/h4-9,13-16,18-19H,10-12,30H2,1-3H3,(H,35,37)/t16-,18+,19-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				Citation and Details BindingDB Entry DOI: 10.7270/Q20V8GZM
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM376818 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)c1nccnc1C |r| Show InChI InChI=1S/C28H30FN7O/c1-16-10-18(12-19(30)11-16)21-6-7-31-15-25(21)35-28(37)22-4-5-24(29)23-13-20(14-34-26(22)23)36(3)27-17(2)32-8-9-33-27/h4-9,13-16,18-19H,10-12,30H2,1-3H3,(H,35,37)/t16-,18+,19-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...				J Med Chem 50: 641-62 (2007) BindingDB Entry DOI: 10.7270/Q2MP55J7
					More data for this Ligand-Target Pair