null

SMILES: COc1ccccc1N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1

InChI Key: InChIKey=MYPHQRYNYWIFDG-ZCNNSNEGSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 376821   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM376821 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES COc1ccccc1N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C30H32FN5O2/c1-18-12-19(14-20(32)13-18)22-10-11-33-17-26(22)35-30(37)23-8-9-25(31)24-15-21(16-34-29(23)24)36(2)27-6-4-5-7-28(27)38-3/h4-11,15-20H,12-14,32H2,1-3H3,(H,35,37)/t18-,19+,20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q20G3NF8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM376821 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES COc1ccccc1N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C30H32FN5O2/c1-18-12-19(14-20(32)13-18)22-10-11-33-17-26(22)35-30(37)23-8-9-25(31)24-15-21(16-34-29(23)24)36(2)27-6-4-5-7-28(27)38-3/h4-11,15-20H,12-14,32H2,1-3H3,(H,35,37)/t18-,19+,20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description Pim-2 kinase assay—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q20G3NF8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM376821 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES COc1ccccc1N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C30H32FN5O2/c1-18-12-19(14-20(32)13-18)22-10-11-33-17-26(22)35-30(37)23-8-9-25(31)24-15-21(16-34-29(23)24)36(2)27-6-4-5-7-28(27)38-3/h4-11,15-20H,12-14,32H2,1-3H3,(H,35,37)/t18-,19+,20-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q20G3NF8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM376821 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES COc1ccccc1N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C30H32FN5O2/c1-18-12-19(14-20(32)13-18)22-10-11-33-17-26(22)35-30(37)23-8-9-25(31)24-15-21(16-34-29(23)24)36(2)27-6-4-5-7-28(27)38-3/h4-11,15-20H,12-14,32H2,1-3H3,(H,35,37)/t18-,19+,20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 641-62 (2007) BindingDB Entry DOI: 10.7270/Q2MP55J7
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM376821 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES COc1ccccc1N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C30H32FN5O2/c1-18-12-19(14-20(32)13-18)22-10-11-33-17-26(22)35-30(37)23-8-9-25(31)24-15-21(16-34-29(23)24)36(2)27-6-4-5-7-28(27)38-3/h4-11,15-20H,12-14,32H2,1-3H3,(H,35,37)/t18-,19+,20-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM376821 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES COc1ccccc1N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C30H32FN5O2/c1-18-12-19(14-20(32)13-18)22-10-11-33-17-26(22)35-30(37)23-8-9-25(31)24-15-21(16-34-29(23)24)36(2)27-6-4-5-7-28(27)38-3/h4-11,15-20H,12-14,32H2,1-3H3,(H,35,37)/t18-,19+,20-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 641-62 (2007) BindingDB Entry DOI: 10.7270/Q2MP55J7
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM376821 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES COc1ccccc1N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C30H32FN5O2/c1-18-12-19(14-20(32)13-18)22-10-11-33-17-26(22)35-30(37)23-8-9-25(31)24-15-21(16-34-29(23)24)36(2)27-6-4-5-7-28(27)38-3/h4-11,15-20H,12-14,32H2,1-3H3,(H,35,37)/t18-,19+,20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM376821 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES COc1ccccc1N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C30H32FN5O2/c1-18-12-19(14-20(32)13-18)22-10-11-33-17-26(22)35-30(37)23-8-9-25(31)24-15-21(16-34-29(23)24)36(2)27-6-4-5-7-28(27)38-3/h4-11,15-20H,12-14,32H2,1-3H3,(H,35,37)/t18-,19+,20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM376821 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES COc1ccccc1N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C30H32FN5O2/c1-18-12-19(14-20(32)13-18)22-10-11-33-17-26(22)35-30(37)23-8-9-25(31)24-15-21(16-34-29(23)24)36(2)27-6-4-5-7-28(27)38-3/h4-11,15-20H,12-14,32H2,1-3H3,(H,35,37)/t18-,19+,20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...				J Med Chem 50: 641-62 (2007) BindingDB Entry DOI: 10.7270/Q2MP55J7
					More data for this Ligand-Target Pair