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SMILES: Cc1[nH]c(=O)c(CN2CCc3c(Cl)cc(N4CC5(C4)CCOCC5)c(Cl)c3C2=O)c2CCNc12

InChI Key: InChIKey=CLHMBIIGBFZQOV-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 378893   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))		BDBM378893
PNG
(5,8-dichloro-2-((7-methyl-5-oxo-5,6-dihydro-1H-pyr...)
Show SMILES Cc1[nH]c(=O)c(CN2CCc3c(Cl)cc(N4CC5(C4)CCOCC5)c(Cl)c3C2=O)c2CCNc12
Show InChI InChI=1S/C25H28Cl2N4O3/c1-14-22-15(2-6-28-22)17(23(32)29-14)11-30-7-3-16-18(26)10-19(21(27)20(16)24(30)33)31-12-25(13-31)4-8-34-9-5-25/h10,28H,2-9,11-13H2,1H3,(H,29,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<0.5n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us...

J Med Chem 51: 4150-69 (2008)


BindingDB Entry DOI: 10.7270/Q2WM1GRX
More data for this
Ligand-Target Pair