BDBM385049 (2S)-N-{(1S)-1-Cyano-2-[4-(4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-6- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 9::US10669245, Example 9

SMILES: CN1C(=O)CSc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1

InChI Key: InChIKey=NSLGCWMFHWURGT-FPOVZHCZSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 385049   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dipeptidyl peptidase 1 (Homo sapiens (Human))	BDBM385049 ((2S)-N-{(1S)-1-Cyano-2-[4-(4-methyl-3-oxo-3,4-dihy...) Show SMILES CN1C(=O)CSc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 Show InChI InChI=1S/C24H26N4O3S/c1-28-20-12-18(7-8-22(20)32-15-23(28)29)17-5-3-16(4-6-17)11-19(13-25)27-24(30)21-14-26-9-2-10-31-21/h3-8,12,19,21,26H,2,9-11,14-15H2,1H3,(H,27,30)/t19-,21-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.9	n/a	n/a	n/a	n/a	n/a	n/a
Novartis					Assay Description The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...				J Med Chem 51: 7049-52 (2008) BindingDB Entry DOI: 10.7270/Q2RJ4MTP
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 1 (Homo sapiens (Human))	BDBM385049 ((2S)-N-{(1S)-1-Cyano-2-[4-(4-methyl-3-oxo-3,4-dihy...) Show SMILES CN1C(=O)CSc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 Show InChI InChI=1S/C24H26N4O3S/c1-28-20-12-18(7-8-22(20)32-15-23(28)29)17-5-3-16(4-6-17)11-19(13-25)27-24(30)21-14-26-9-2-10-31-21/h3-8,12,19,21,26H,2,9-11,14-15H2,1H3,(H,27,30)/t19-,21-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	12.9	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 1 (Homo sapiens (Human))	BDBM385049 ((2S)-N-{(1S)-1-Cyano-2-[4-(4-methyl-3-oxo-3,4-dihy...) Show SMILES CN1C(=O)CSc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 Show InChI InChI=1S/C24H26N4O3S/c1-28-20-12-18(7-8-22(20)32-15-23(28)29)17-5-3-16(4-6-17)11-19(13-25)27-24(30)21-14-26-9-2-10-31-21/h3-8,12,19,21,26H,2,9-11,14-15H2,1H3,(H,27,30)/t19-,21-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.9	n/a	n/a	n/a	n/a	n/a	n/a
ASTRAZENECA AB US Patent					Assay Description The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...				US Patent US10669245 (2020)
					More data for this Ligand-Target Pair