BDBM385055 (2S)-N-{(1S)-1-Cyano-2-[4-(7-fluoro-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide::US10287258, Example 15::US10669245, Example 15

SMILES: Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1

InChI Key: InChIKey=IVHOZTBKWBUDMJ-PXNSSMCTSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 385055   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dipeptidyl peptidase I (Homo sapiens (Human))	BDBM385055 ((2S)-N-{(1S)-1-Cyano-2-[4-(7-fluoro-3-methyl-2-oxo...) Show SMILES Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 Show InChI InChI=1S/C23H23FN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.13	n/a	n/a	n/a	n/a	n/a	n/a
Novartis					Assay Description The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...				J Med Chem 51: 7049-52 (2008) BindingDB Entry DOI: 10.7270/Q2RJ4MTP
					More data for this Ligand-Target Pair
Dipeptidyl peptidase I (Homo sapiens (Human))	BDBM385055 ((2S)-N-{(1S)-1-Cyano-2-[4-(7-fluoro-3-methyl-2-oxo...) Show SMILES Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 Show InChI InChI=1S/C23H23FN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	5.13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase I (Homo sapiens (Human))	BDBM385055 ((2S)-N-{(1S)-1-Cyano-2-[4-(7-fluoro-3-methyl-2-oxo...) Show SMILES Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 Show InChI InChI=1S/C23H23FN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.13	n/a	n/a	n/a	n/a	n/a	n/a
ASTRAZENECA AB US Patent					Assay Description The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...				US Patent US10669245 (2020)
					More data for this Ligand-Target Pair