BDBM385065 (2S)-N-[(1S)-1-Cyano-2-{4-[2-oxo-3-(tetrahydro-2H-pyran-4-ylmethyl)-2,3-dihydro- 1,3-benzoxazol-5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 25::US10669245, Example 25

SMILES: O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2oc(=O)n(CC3CCOCC3)c2c1)C#N)[C@@H]1CNCCCO1

InChI Key: InChIKey=KFOHIWSKADTAQW-OZXSUGGESA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 385065   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dipeptidyl peptidase I (Homo sapiens (Human))	BDBM385065 ((2S)-N-[(1S)-1-Cyano-2-{4-[2-oxo-3-(tetrahydro-2H-...) Show SMILES O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2oc(=O)n(CC3CCOCC3)c2c1)C#N)[C@@H]1CNCCCO1 Show InChI InChI=1S/C28H32N4O5/c29-16-23(31-27(33)26-17-30-10-1-11-36-26)14-19-2-4-21(5-3-19)22-6-7-25-24(15-22)32(28(34)37-25)18-20-8-12-35-13-9-20/h2-7,15,20,23,26,30H,1,8-14,17-18H2,(H,31,33)/t23-,26-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.7	n/a	n/a	n/a	n/a	n/a	n/a
Novartis					Assay Description The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...				J Med Chem 51: 7049-52 (2008) BindingDB Entry DOI: 10.7270/Q2RJ4MTP
					More data for this Ligand-Target Pair
Dipeptidyl peptidase I (Homo sapiens (Human))	BDBM385065 ((2S)-N-[(1S)-1-Cyano-2-{4-[2-oxo-3-(tetrahydro-2H-...) Show SMILES O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2oc(=O)n(CC3CCOCC3)c2c1)C#N)[C@@H]1CNCCCO1 Show InChI InChI=1S/C28H32N4O5/c29-16-23(31-27(33)26-17-30-10-1-11-36-26)14-19-2-4-21(5-3-19)22-6-7-25-24(15-22)32(28(34)37-25)18-20-8-12-35-13-9-20/h2-7,15,20,23,26,30H,1,8-14,17-18H2,(H,31,33)/t23-,26-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	10.7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase I (Homo sapiens (Human))	BDBM385065 ((2S)-N-[(1S)-1-Cyano-2-{4-[2-oxo-3-(tetrahydro-2H-...) Show SMILES O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2oc(=O)n(CC3CCOCC3)c2c1)C#N)[C@@H]1CNCCCO1 Show InChI InChI=1S/C28H32N4O5/c29-16-23(31-27(33)26-17-30-10-1-11-36-26)14-19-2-4-21(5-3-19)22-6-7-25-24(15-22)32(28(34)37-25)18-20-8-12-35-13-9-20/h2-7,15,20,23,26,30H,1,8-14,17-18H2,(H,31,33)/t23-,26-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.7	n/a	n/a	n/a	n/a	n/a	n/a
ASTRAZENECA AB US Patent					Assay Description The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...				US Patent US10669245 (2020)
					More data for this Ligand-Target Pair