null

SMILES: NC(=O)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc(OC(F)F)cc1

InChI Key: InChIKey=JKPYXYOCVLDBJL-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 387065   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor X (Homo sapiens (Human))	BDBM387065 (1-(4-(Difluoromethoxy)phenyl)-7-oxo-6-(1-(3-oxomor...) Show SMILES NC(=O)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc(OC(F)F)cc1 Show InChI InChI=1S/C23H26F2N6O5/c24-23(25)36-16-3-1-15(2-4-16)31-20-17(19(27-31)21(26)33)7-10-29(22(20)34)14-5-8-28(9-6-14)30-11-12-35-13-18(30)32/h1-4,14,23H,5-13H2,(H2,26,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...				J Med Chem 51: 1681-94 (2008) BindingDB Entry DOI: 10.7270/Q2F1921P
					More data for this Ligand-Target Pair
Coagulation factor V/Coagulation factor X/Serine/threonine-protein kinase BRSK2 (Homo sapiens (Human))	BDBM387065 (1-(4-(Difluoromethoxy)phenyl)-7-oxo-6-(1-(3-oxomor...) Show SMILES NC(=O)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc(OC(F)F)cc1 Show InChI InChI=1S/C23H26F2N6O5/c24-23(25)36-16-3-1-15(2-4-16)31-20-17(19(27-31)21(26)33)7-10-29(22(20)34)14-5-8-28(9-6-14)30-11-12-35-13-18(30)32/h1-4,14,23H,5-13H2,(H2,26,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...				J Med Chem 51: 1681-94 (2008) BindingDB Entry DOI: 10.7270/Q2F1921P
					More data for this Ligand-Target Pair
Coagulation factor X (Rattus norvegicus (rat))	BDBM387065 (1-(4-(Difluoromethoxy)phenyl)-7-oxo-6-(1-(3-oxomor...) Show SMILES NC(=O)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc(OC(F)F)cc1 Show InChI InChI=1S/C23H26F2N6O5/c24-23(25)36-16-3-1-15(2-4-16)31-20-17(19(27-31)21(26)33)7-10-29(22(20)34)14-5-8-28(9-6-14)30-11-12-35-13-18(30)32/h1-4,14,23H,5-13H2,(H2,26,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...				J Med Chem 51: 1681-94 (2008) BindingDB Entry DOI: 10.7270/Q2F1921P
					More data for this Ligand-Target Pair
Serine protease 1 (Homo sapiens (Human))	BDBM387065 (1-(4-(Difluoromethoxy)phenyl)-7-oxo-6-(1-(3-oxomor...) Show SMILES NC(=O)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc(OC(F)F)cc1 Show InChI InChI=1S/C23H26F2N6O5/c24-23(25)36-16-3-1-15(2-4-16)31-20-17(19(27-31)21(26)33)7-10-29(22(20)34)14-5-8-28(9-6-14)30-11-12-35-13-18(30)32/h1-4,14,23H,5-13H2,(H2,26,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description Trypsin: In the assay for measuring the inhibition of human trypsin activity buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2) is used. The IC50 is measur...				J Med Chem 51: 1681-94 (2008) BindingDB Entry DOI: 10.7270/Q2F1921P
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM387065 (1-(4-(Difluoromethoxy)phenyl)-7-oxo-6-(1-(3-oxomor...) Show SMILES NC(=O)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc(OC(F)F)cc1 Show InChI InChI=1S/C23H26F2N6O5/c24-23(25)36-16-3-1-15(2-4-16)31-20-17(19(27-31)21(26)33)7-10-29(22(20)34)14-5-8-28(9-6-14)30-11-12-35-13-18(30)32/h1-4,14,23H,5-13H2,(H2,26,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description Thrombin: In the assay for measuring the inhibition of human thrombin activity buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2) is used. The IC50 is m...				J Med Chem 51: 1681-94 (2008) BindingDB Entry DOI: 10.7270/Q2F1921P
					More data for this Ligand-Target Pair