BDBM389583 N-{2-[(E)-2-(4- methoxyphenyl)vinyl]quinazolin-4- yl}propane-1,3-diamine::US9951029, 83

SMILES: COc1ccc(\C=C\c2nc(NCCCN)c3ccccc3n2)cc1

InChI Key: InChIKey=IMJVYRKXEQFISU-FMIVXFBMSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 389583   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM389583 (N-{2-[(E)-2-(4- methoxyphenyl)vinyl]quinazolin-4- ...) Show SMILES COc1ccc(\C=C\c2nc(NCCCN)c3ccccc3n2)cc1 Show InChI InChI=1S/C20H22N4O/c1-25-16-10-7-15(8-11-16)9-12-19-23-18-6-3-2-5-17(18)20(24-19)22-14-4-13-21/h2-3,5-12H,4,13-14,21H2,1H3,(H,22,23,24)/b12-9+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	134	n/a	n/a	n/a	n/a	n/a	n/a
Georgia Institute of Technology					Assay Description FLT3(ITD) biochemical assays were performed on two different assay system platforms, using Transcreener® ADP Assay FP method (BellBrook Labs, Madison...				J Med Chem 52: 456-68 (2009) BindingDB Entry DOI: 10.7270/Q2NG4T0S
					More data for this Ligand-Target Pair