BDBM389585 N,N-dimethyl-N'-{2-[(E)-2-(2- thienyl)vinyl]benzo[g]quinazolin-4- yl}ethane-1,2-diamine::US9951029, 85

SMILES: CN(C)CCNc1nc(\C=C\c2cccs2)nc2cc3ccccc3cc12

InChI Key: InChIKey=GAEVEHHBAUZFLY-MDZDMXLPSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 389585   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM389585 (N,N-dimethyl-N'-{2-[(E)-2-(2- thienyl)vinyl]benzo[...) Show SMILES CN(C)CCNc1nc(\C=C\c2cccs2)nc2cc3ccccc3cc12 Show InChI InChI=1S/C22H22N4S/c1-26(2)12-11-23-22-19-14-16-6-3-4-7-17(16)15-20(19)24-21(25-22)10-9-18-8-5-13-27-18/h3-10,13-15H,11-12H2,1-2H3,(H,23,24,25)/b10-9+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.21E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vichem Chemie Research Ltd Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IM...				Eur J Med Chem 184: (2019) Article DOI: 10.1016/j.ejmech.2019.111710
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM389585 (N,N-dimethyl-N'-{2-[(E)-2-(2- thienyl)vinyl]benzo[...) Show SMILES CN(C)CCNc1nc(\C=C\c2cccs2)nc2cc3ccccc3cc12 Show InChI InChI=1S/C22H22N4S/c1-26(2)12-11-23-22-19-14-16-6-3-4-7-17(16)15-20(19)24-21(25-22)10-9-18-8-5-13-27-18/h3-10,13-15H,11-12H2,1-2H3,(H,23,24,25)/b10-9+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	950	n/a	n/a	n/a	n/a	n/a	n/a
Georgia Institute of Technology					Assay Description FLT3(ITD) biochemical assays were performed on two different assay system platforms, using Transcreener® ADP Assay FP method (BellBrook Labs, Madison...				J Med Chem 52: 456-68 (2009) BindingDB Entry DOI: 10.7270/Q2NG4T0S
					More data for this Ligand-Target Pair