BDBM389586 N,N-dimethyl-N'-(2-{(E)-2-[4- (methylthio)phenyl]vinyl}quinazolin- 4-yl)ethane-1,2-diamine::US9951029, 88

SMILES: CSc1ccc(\C=C\c2nc(NCCN(C)C)c3ccccc3n2)cc1

InChI Key: InChIKey=GZTYTAOGJJGFNK-JLHYYAGUSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 389586   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM389586 (N,N-dimethyl-N'-(2-{(E)-2-[4- (methylthio)phenyl]v...) Show SMILES CSc1ccc(\C=C\c2nc(NCCN(C)C)c3ccccc3n2)cc1 Show InChI InChI=1S/C21H24N4S/c1-25(2)15-14-22-21-18-6-4-5-7-19(18)23-20(24-21)13-10-16-8-11-17(26-3)12-9-16/h4-13H,14-15H2,1-3H3,(H,22,23,24)/b13-10+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	461	n/a	n/a	n/a	n/a	n/a	n/a
Georgia Institute of Technology					Assay Description FLT3(ITD) biochemical assays were performed on two different assay system platforms, using Transcreener® ADP Assay FP method (BellBrook Labs, Madison...				J Med Chem 52: 456-68 (2009) BindingDB Entry DOI: 10.7270/Q2NG4T0S
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM389586 (N,N-dimethyl-N'-(2-{(E)-2-[4- (methylthio)phenyl]v...) Show SMILES CSc1ccc(\C=C\c2nc(NCCN(C)C)c3ccccc3n2)cc1 Show InChI InChI=1S/C21H24N4S/c1-25(2)15-14-22-21-18-6-4-5-7-19(18)23-20(24-21)13-10-16-8-11-17(26-3)12-9-16/h4-13H,14-15H2,1-3H3,(H,22,23,24)/b13-10+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
Vichem Chemie Research Ltd Curated by ChEMBL					Assay Description Inhibition of FLT3 D835Y (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IMAP-FP...				Eur J Med Chem 184: (2019) Article DOI: 10.1016/j.ejmech.2019.111710
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM389586 (N,N-dimethyl-N'-(2-{(E)-2-[4- (methylthio)phenyl]v...) Show SMILES CSc1ccc(\C=C\c2nc(NCCN(C)C)c3ccccc3n2)cc1 Show InChI InChI=1S/C21H24N4S/c1-25(2)15-14-22-21-18-6-4-5-7-19(18)23-20(24-21)13-10-16-8-11-17(26-3)12-9-16/h4-13H,14-15H2,1-3H3,(H,22,23,24)/b13-10+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Vichem Chemie Research Ltd Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IM...				Eur J Med Chem 184: (2019) Article DOI: 10.1016/j.ejmech.2019.111710
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM389586 (N,N-dimethyl-N'-(2-{(E)-2-[4- (methylthio)phenyl]v...) Show SMILES CSc1ccc(\C=C\c2nc(NCCN(C)C)c3ccccc3n2)cc1 Show InChI InChI=1S/C21H24N4S/c1-25(2)15-14-22-21-18-6-4-5-7-19(18)23-20(24-21)13-10-16-8-11-17(26-3)12-9-16/h4-13H,14-15H2,1-3H3,(H,22,23,24)/b13-10+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.78E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vichem Chemie Research Ltd Curated by ChEMBL					Assay Description Inhibition of wildtype FLT3 (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IMAP...				Eur J Med Chem 184: (2019) Article DOI: 10.1016/j.ejmech.2019.111710
					More data for this Ligand-Target Pair