BDBM389595 N'-{6-chloro-2-[(E)-2-(2- thienyl)vinyl]quinazolin-4-yl}-N,N- diethylethane-1,2-diamine::US9951029, 104

SMILES: CCN(CC)CCNc1nc(\C=C\c2cccs2)nc2ccc(Cl)cc12

InChI Key: InChIKey=APKKGWIEZZVPKI-CSKARUKUSA-N

Data: 2 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 389595   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM389595 (N'-{6-chloro-2-[(E)-2-(2- thienyl)vinyl]quinazolin...) Show SMILES CCN(CC)CCNc1nc(\C=C\c2cccs2)nc2ccc(Cl)cc12 Show InChI InChI=1S/C20H23ClN4S/c1-3-25(4-2)12-11-22-20-17-14-15(21)7-9-18(17)23-19(24-20)10-8-16-6-5-13-26-16/h5-10,13-14H,3-4,11-12H2,1-2H3,(H,22,23,24)/b10-8+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.17E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vichem Chemie Research Ltd Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IM...				Eur J Med Chem 184: (2019) Article DOI: 10.1016/j.ejmech.2019.111710
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM389595 (N'-{6-chloro-2-[(E)-2-(2- thienyl)vinyl]quinazolin...) Show SMILES CCN(CC)CCNc1nc(\C=C\c2cccs2)nc2ccc(Cl)cc12 Show InChI InChI=1S/C20H23ClN4S/c1-3-25(4-2)12-11-22-20-17-14-15(21)7-9-18(17)23-19(24-20)10-8-16-6-5-13-26-16/h5-10,13-14H,3-4,11-12H2,1-2H3,(H,22,23,24)/b10-8+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
Georgia Institute of Technology					Assay Description FLT3(ITD) biochemical assays were performed on two different assay system platforms, using Transcreener® ADP Assay FP method (BellBrook Labs, Madison...				J Med Chem 52: 456-68 (2009) BindingDB Entry DOI: 10.7270/Q2NG4T0S
					More data for this Ligand-Target Pair