BDBM389607 N'-{6-chloro-2-[(E)-2-(4- isopropylphenyl)vinyl]quinazolin-4- yl}-N,N-diethylpropane-1,3-diamine::US9951029, 124

SMILES: CCN(CC)CCCNc1nc(\C=C\c2ccc(cc2)C(C)C)nc2ccc(Cl)cc12

InChI Key: InChIKey=FSQXNAHEBFNFAZ-XNTDXEJSSA-N

Data: 2 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 389607   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM389607 (N'-{6-chloro-2-[(E)-2-(4- isopropylphenyl)vinyl]qu...) Show SMILES CCN(CC)CCCNc1nc(\C=C\c2ccc(cc2)C(C)C)nc2ccc(Cl)cc12 Show InChI InChI=1S/C26H33ClN4/c1-5-31(6-2)17-7-16-28-26-23-18-22(27)13-14-24(23)29-25(30-26)15-10-20-8-11-21(12-9-20)19(3)4/h8-15,18-19H,5-7,16-17H2,1-4H3,(H,28,29,30)/b15-10+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	810	n/a	n/a	n/a	n/a	n/a	n/a
Vichem Chemie Research Ltd Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IM...				Eur J Med Chem 184: (2019) Article DOI: 10.1016/j.ejmech.2019.111710
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM389607 (N'-{6-chloro-2-[(E)-2-(4- isopropylphenyl)vinyl]qu...) Show SMILES CCN(CC)CCCNc1nc(\C=C\c2ccc(cc2)C(C)C)nc2ccc(Cl)cc12 Show InChI InChI=1S/C26H33ClN4/c1-5-31(6-2)17-7-16-28-26-23-18-22(27)13-14-24(23)29-25(30-26)15-10-20-8-11-21(12-9-20)19(3)4/h8-15,18-19H,5-7,16-17H2,1-4H3,(H,28,29,30)/b15-10+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.97E+3	n/a	n/a	n/a	n/a	n/a	n/a
Georgia Institute of Technology					Assay Description FLT3(ITD) biochemical assays were performed on two different assay system platforms, using Transcreener® ADP Assay FP method (BellBrook Labs, Madison...				J Med Chem 52: 456-68 (2009) BindingDB Entry DOI: 10.7270/Q2NG4T0S
					More data for this Ligand-Target Pair