BDBM389616 N'-(6-chloro-2-{(E)-2-[4- (methylsulfonyl)phenyl]vinyl}quinazolin- 4-yl)-N,N-diethylethane-1,2- diamine::US9951029, 133

SMILES: CCN(CC)CCNc1nc(\C=C\c2ccc(cc2)S(C)(=O)=O)nc2ccc(Cl)cc12

InChI Key: InChIKey=QQMPDLYQWNTWCK-MDWZMJQESA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 389616   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM389616 (N'-(6-chloro-2-{(E)-2-[4- (methylsulfonyl)phenyl]v...) Show SMILES CCN(CC)CCNc1nc(\C=C\c2ccc(cc2)S(C)(=O)=O)nc2ccc(Cl)cc12 Show InChI InChI=1S/C23H27ClN4O2S/c1-4-28(5-2)15-14-25-23-20-16-18(24)9-12-21(20)26-22(27-23)13-8-17-6-10-19(11-7-17)31(3,29)30/h6-13,16H,4-5,14-15H2,1-3H3,(H,25,26,27)/b13-8+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a	n/a
Georgia Institute of Technology					Assay Description FLT3(ITD) biochemical assays were performed on two different assay system platforms, using Transcreener® ADP Assay FP method (BellBrook Labs, Madison...				J Med Chem 52: 456-68 (2009) BindingDB Entry DOI: 10.7270/Q2NG4T0S
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM389616 (N'-(6-chloro-2-{(E)-2-[4- (methylsulfonyl)phenyl]v...) Show SMILES CCN(CC)CCNc1nc(\C=C\c2ccc(cc2)S(C)(=O)=O)nc2ccc(Cl)cc12 Show InChI InChI=1S/C23H27ClN4O2S/c1-4-28(5-2)15-14-25-23-20-16-18(24)9-12-21(20)26-22(27-23)13-8-17-6-10-19(11-7-17)31(3,29)30/h6-13,16H,4-5,14-15H2,1-3H3,(H,25,26,27)/b13-8+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Vichem Chemie Research Ltd Curated by ChEMBL					Assay Description Inhibition of FLT3 D835Y (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IMAP-FP...				Eur J Med Chem 184: (2019) Article DOI: 10.1016/j.ejmech.2019.111710
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM389616 (N'-(6-chloro-2-{(E)-2-[4- (methylsulfonyl)phenyl]v...) Show SMILES CCN(CC)CCNc1nc(\C=C\c2ccc(cc2)S(C)(=O)=O)nc2ccc(Cl)cc12 Show InChI InChI=1S/C23H27ClN4O2S/c1-4-28(5-2)15-14-25-23-20-16-18(24)9-12-21(20)26-22(27-23)13-8-17-6-10-19(11-7-17)31(3,29)30/h6-13,16H,4-5,14-15H2,1-3H3,(H,25,26,27)/b13-8+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.13E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vichem Chemie Research Ltd Curated by ChEMBL					Assay Description Inhibition of wildtype FLT3 (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IMAP...				Eur J Med Chem 184: (2019) Article DOI: 10.1016/j.ejmech.2019.111710
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM389616 (N'-(6-chloro-2-{(E)-2-[4- (methylsulfonyl)phenyl]v...) Show SMILES CCN(CC)CCNc1nc(\C=C\c2ccc(cc2)S(C)(=O)=O)nc2ccc(Cl)cc12 Show InChI InChI=1S/C23H27ClN4O2S/c1-4-28(5-2)15-14-25-23-20-16-18(24)9-12-21(20)26-22(27-23)13-8-17-6-10-19(11-7-17)31(3,29)30/h6-13,16H,4-5,14-15H2,1-3H3,(H,25,26,27)/b13-8+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a	n/a
Vichem Chemie Research Ltd Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IM...				Eur J Med Chem 184: (2019) Article DOI: 10.1016/j.ejmech.2019.111710
					More data for this Ligand-Target Pair