BDBM392853 US10301306, Example 51

SMILES: Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccc(cc2F)C#N)c1-c1ccncc1

InChI Key: InChIKey=SONGNMIAVJBJLQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 392853   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392853 (US10301306, Example 51) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccc(cc2F)C#N)c1-c1ccncc1 Show InChI InChI=1S/C26H18F2N4O/c27-20-5-3-17(4-6-20)23-24-22(9-12-31-26(24)33)32(25(23)18-7-10-30-11-8-18)15-19-2-1-16(14-29)13-21(19)28/h1-8,10-11,13H,9,12,15H2,(H,31,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair