BDBM392866 US10301306, Example 64

SMILES: Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccc(F)cc2F)c1-c1ccncc1

InChI Key: InChIKey=RBRDSLKVWPVLJP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 392866   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392866 (US10301306, Example 64) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccc(F)cc2F)c1-c1ccncc1 Show InChI InChI=1S/C25H18F3N3O/c26-18-4-1-15(2-5-18)22-23-21(9-12-30-25(23)32)31(24(22)16-7-10-29-11-8-16)14-17-3-6-19(27)13-20(17)28/h1-8,10-11,13H,9,12,14H2,(H,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair