BindingDB logo
myBDB logout

null

SMILES: Fc1ccc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2ccc(F)c(F)c2)c(c1)C#N

InChI Key: InChIKey=YKNFMLGFOHSXRZ-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 392917   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Receptor-interacting serine/threonine-protein kinase 3


(Homo sapiens (Human))		BDBM392917
PNG
(US10301306, Example 115)
Show SMILES Fc1ccc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2ccc(F)c(F)c2)c(c1)C#N
Show InChI InChI=1S/C26H17F3N4O/c27-19-3-1-17(18(11-19)13-30)14-33-22-7-10-32-26(34)24(22)23(16-2-4-20(28)21(29)12-16)25(33)15-5-8-31-9-6-15/h1-6,8-9,11-12H,7,10,14H2,(H,32,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<30n/an/an/an/an/an/a



GSK



Assay Description
The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...

Bioorg Med Chem Lett 18: 5018-22 (2008)


BindingDB Entry DOI: 10.7270/Q2M90C19
More data for this
Ligand-Target Pair