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SMILES: Fc1ccc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2cccc(c2)C(F)(F)F)c(c1)C#N

InChI Key: InChIKey=ABXNNMAETLSPIP-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 392925   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Receptor-interacting serine/threonine-protein kinase 3


(Homo sapiens (Human))		BDBM392925
PNG
(US10301306, Example 123)
Show SMILES Fc1ccc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2cccc(c2)C(F)(F)F)c(c1)C#N
Show InChI InChI=1S/C27H18F4N4O/c28-21-5-4-18(19(13-21)14-32)15-35-22-8-11-34-26(36)24(22)23(25(35)16-6-9-33-10-7-16)17-2-1-3-20(12-17)27(29,30)31/h1-7,9-10,12-13H,8,11,15H2,(H,34,36)
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n/an/a<30n/an/an/an/an/an/a



GSK



Assay Description
The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...

Bioorg Med Chem Lett 18: 5018-22 (2008)


BindingDB Entry DOI: 10.7270/Q2M90C19
More data for this
Ligand-Target Pair