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SMILES: Fc1ccc(Cn2c3CCNC(=O)c3c(-c3ccsc3)c2-c2ccncc2)c(c1)C#N

InChI Key: InChIKey=CNGDERBQDCUMDW-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 392930   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Receptor-interacting serine/threonine-protein kinase 3


(Homo sapiens (Human))		BDBM392930
PNG
(US10301306, Example 128)
Show SMILES Fc1ccc(Cn2c3CCNC(=O)c3c(-c3ccsc3)c2-c2ccncc2)c(c1)C#N
Show InChI InChI=1S/C24H17FN4OS/c25-19-2-1-16(18(11-19)12-26)13-29-20-5-9-28-24(30)22(20)21(17-6-10-31-14-17)23(29)15-3-7-27-8-4-15/h1-4,6-8,10-11,14H,5,9,13H2,(H,28,30)
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n/an/a<30n/an/an/an/an/an/a



GSK



Assay Description
The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...

Bioorg Med Chem Lett 18: 5018-22 (2008)


BindingDB Entry DOI: 10.7270/Q2M90C19
More data for this
Ligand-Target Pair