BDBM392959 1-(2-Fluoro-4-(trifluoromethyl)benzyl)-3-(4-fluorophenyl)-2-(pyridin-4-yl)-1H-pyrrolo[3,2-c]pyridin-4(5H)-one::US10301306, Example 157
SMILES: Fc1ccc(cc1)-c1c(-c2ccncc2)n(Cc2ccc(cc2F)C(F)(F)F)c2cc[nH]c(=O)c12
InChI Key: InChIKey=ASBWNOPXSMYGII-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human)) | BDBM392959 (1-(2-Fluoro-4-(trifluoromethyl)benzyl)-3-(4-fluoro...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <30 | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T... | Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19 | |||||||||||
More data for this Ligand-Target Pair |