BDBM39340 4-Amino-N-(pyrimidin-2-yl) benzenesulfonamide (Sulfadiazine) (14)::MLS000069725::SMR000058213::SULFAPYRIDINE::cid_5336
SMILES: Nc1ccc(cc1)S(=O)(=O)Nc1ccccn1
InChI Key: InChIKey=GECHUMIMRBOMGK-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM39340 (4-Amino-N-(pyrimidin-2-yl) benzenesulfonamide (Sul...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem Patents | Article PubMed | 348 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Ondokuz Mayis University | Assay Description The CA activity was assayed by following the change in absorbance at 348 nm of 4-NPA to 4-nitrophenylate ion over a period of 3 min at 25°C using a s... | J Enzyme Inhib Med Chem 27: 845-8 (2012) Article DOI: 10.3109/14756366.2011.621122 BindingDB Entry DOI: 10.7270/Q27P8X9X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 6 (CA-VI) (Homo sapiens (Human)) | BDBM39340 (4-Amino-N-(pyrimidin-2-yl) benzenesulfonamide (Sul...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem Patents | Article PubMed | 1.17E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Ondokuz Mayis University | Assay Description The CA activity was assayed by following the change in absorbance at 348 nm of 4-NPA to 4-nitrophenylate ion over a period of 3 min at 25°C using a s... | J Enzyme Inhib Med Chem 27: 845-8 (2012) Article DOI: 10.3109/14756366.2011.621122 BindingDB Entry DOI: 10.7270/Q27P8X9X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM39340 (4-Amino-N-(pyrimidin-2-yl) benzenesulfonamide (Sul...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem Patents | Article PubMed | 2.62E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Ondokuz Mayis University | Assay Description The CA activity was assayed by following the change in absorbance at 348 nm of 4-NPA to 4-nitrophenylate ion over a period of 3 min at 25°C using a s... | J Enzyme Inhib Med Chem 27: 845-8 (2012) Article DOI: 10.3109/14756366.2011.621122 BindingDB Entry DOI: 10.7270/Q27P8X9X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 3 (CA III) (Bos taurus (Cattle)) | BDBM39340 (4-Amino-N-(pyrimidin-2-yl) benzenesulfonamide (Sul...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem Patents | Article PubMed | 9.32E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Ondokuz Mayis University | Assay Description The CA activity was assayed by following the change in absorbance at 348 nm of 4-NPA to 4-nitrophenylate ion over a period of 3 min at 25°C using a s... | J Enzyme Inhib Med Chem 27: 845-8 (2012) Article DOI: 10.3109/14756366.2011.621122 BindingDB Entry DOI: 10.7270/Q27P8X9X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (West Nile virus) | BDBM39340 (4-Amino-N-(pyrimidin-2-yl) benzenesulfonamide (Sul...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem Patents | PCBioAssay | n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Molecular Library Screening Center Curated by PubChem BioAssay | Assay Description The HTS assay to identify Inhibitors of West Nile Virus (WNV) NS2bNS3 Proteinase was proposed by Dr Alex Strongin of the Burnham Institute XO1-MH0776... | PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2222S6W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
protein-arginine deiminase type-4 (Homo sapiens (Human)) | BDBM39340 (4-Amino-N-(pyrimidin-2-yl) benzenesulfonamide (Sul...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | >1.00E+7 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Carolina Curated by ChEMBL | Assay Description Inhibition of PAD4 by ABPP-based assay | Bioorg Med Chem 16: 739-45 (2008) Article DOI: 10.1016/j.bmc.2007.10.021 BindingDB Entry DOI: 10.7270/Q24F1RKF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM39340 (4-Amino-N-(pyrimidin-2-yl) benzenesulfonamide (Sul...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | 2.84E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Ataturk University | Assay Description Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ... | J Enzyme Inhib Med Chem 27: 818-24 (2012) Article DOI: 10.3109/14756366.2011.617745 BindingDB Entry DOI: 10.7270/Q2G73CKP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM39340 (4-Amino-N-(pyrimidin-2-yl) benzenesulfonamide (Sul...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | 276 | n/a | n/a | n/a | n/a | n/a | n/a |
Ataturk University | Assay Description Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ... | J Enzyme Inhib Med Chem 27: 818-24 (2012) Article DOI: 10.3109/14756366.2011.617745 BindingDB Entry DOI: 10.7270/Q2G73CKP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 6 (CA-VI) (Homo sapiens (Human)) | BDBM39340 (4-Amino-N-(pyrimidin-2-yl) benzenesulfonamide (Sul...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | 1.55E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Ataturk University | Assay Description Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ... | J Enzyme Inhib Med Chem 27: 818-24 (2012) Article DOI: 10.3109/14756366.2011.617745 BindingDB Entry DOI: 10.7270/Q2G73CKP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystine/glutamate transporter (Homo sapiens (Human)) | BDBM39340 (4-Amino-N-(pyrimidin-2-yl) benzenesulfonamide (Sul...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Johns Hopkins University Curated by ChEMBL | Assay Description Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc... | Bioorg Med Chem Lett 21: 6184-7 (2011) Article DOI: 10.1016/j.bmcl.2011.07.081 BindingDB Entry DOI: 10.7270/Q21V5FCR | |||||||||||
More data for this Ligand-Target Pair |