BDBM393426 N-(5-((2S,5R,6S)-5-amino-6- fluorooxepan-2-yl)-1-methyl- 1H-pyrazol-4-yl)-2-((R)-6,8- difluoro-4-hydroxychroman-7- yl)thiazole-4-carboxamide::US9963446, Example 112

SMILES: Cn1ncc(NC(=O)c2csc(n2)-c2c(F)cc3[C@H](O)CCOc3c2F)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1

InChI Key: InChIKey=JUZOWLSJBBSRIU-KFZJALRRSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 393426   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM393426 (N-(5-((2S,5R,6S)-5-amino-6- fluorooxepan-2-yl)-1-m...) Show SMILES Cn1ncc(NC(=O)c2csc(n2)-c2c(F)cc3[C@H](O)CCOc3c2F)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 |r| Show InChI InChI=1S/C23H24F3N5O4S/c1-31-20(17-3-2-13(27)12(25)8-35-17)14(7-28-31)29-22(33)15-9-36-23(30-15)18-11(24)6-10-16(32)4-5-34-21(10)19(18)26/h6-7,9,12-13,16-17,32H,2-5,8,27H2,1H3,(H,29,33)/t12-,13-,16-,17+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Institute for Medical Research					Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...				Chem Biol Drug Des 71: 131-9 (2008) BindingDB Entry DOI: 10.7270/Q22B91B0
					More data for this Ligand-Target Pair