BDBM394655 US10308615, Example 12::preparation of {2-[(pyridin-3-ylmethyl)amino]pyrimidin-5-yl}[3-(trifluoromethyl)phenyl]methanone
SMILES: FC(F)(F)c1cccc(c1)C(=O)c1cnc(NCc2cccnc2)nc1
InChI Key: InChIKey=IKEXSEJPRXVFPJ-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pantetheinase (Homo sapiens (Human)) | BDBM394655 (US10308615, Example 12 | preparation of {2-[(pyrid...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter... | Bioorg Med Chem Lett 19: 3664-8 (2009) BindingDB Entry DOI: 10.7270/Q22809Z8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pantetheinase (Homo sapiens (Human)) | BDBM394655 (US10308615, Example 12 | preparation of {2-[(pyrid...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter... | Bioorg Med Chem Lett 19: 3664-8 (2009) BindingDB Entry DOI: 10.7270/Q22809Z8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pantetheinase (Homo sapiens (Human)) | BDBM394655 (US10308615, Example 12 | preparation of {2-[(pyrid...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter... | Bioorg Med Chem Lett 19: 3664-8 (2009) BindingDB Entry DOI: 10.7270/Q22809Z8 | |||||||||||
More data for this Ligand-Target Pair |