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SMILES: Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(CCCOCc3ccccc3)c2n1

InChI Key: InChIKey=CEXRURTZESMLHM-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4060   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM4060 (2-Amino-8-(3-benzyloxypropyl)-6-(2,6-dichloropheny...) Show SMILES Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(CCCOCc3ccccc3)c2n1 |(-6.98,-1.25,;-5.65,-.48,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,;-1.65,-1.25,;-1.65,-2.79,;-.32,-3.56,;-.32,-5.1,;1.02,-5.87,;1.02,-7.41,;2.35,-8.18,;2.35,-9.72,;3.69,-10.49,;5.02,-9.72,;5.02,-8.18,;3.69,-7.41,;-2.98,-.48,;-4.32,-1.25,)| Show InChI InChI=1S/C23H20Cl2N4O2/c24-18-8-4-9-19(25)20(18)17-12-16-13-27-23(26)28-21(16)29(22(17)30)10-5-11-31-14-15-6-2-1-3-7-15/h1-4,6-9,12-13H,5,10-11,14H2,(H2,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 41: 4365-77 (1998) Article DOI: 10.1021/jm980398y BindingDB Entry DOI: 10.7270/Q2CC0XWN
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4060 (2-Amino-8-(3-benzyloxypropyl)-6-(2,6-dichloropheny...) Show SMILES Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(CCCOCc3ccccc3)c2n1 |(-6.98,-1.25,;-5.65,-.48,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,;-1.65,-1.25,;-1.65,-2.79,;-.32,-3.56,;-.32,-5.1,;1.02,-5.87,;1.02,-7.41,;2.35,-8.18,;2.35,-9.72,;3.69,-10.49,;5.02,-9.72,;5.02,-8.18,;3.69,-7.41,;-2.98,-.48,;-4.32,-1.25,)| Show InChI InChI=1S/C23H20Cl2N4O2/c24-18-8-4-9-19(25)20(18)17-12-16-13-27-23(26)28-21(16)29(22(17)30)10-5-11-31-14-15-6-2-1-3-7-15/h1-4,6-9,12-13H,5,10-11,14H2,(H2,26,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 41: 4365-77 (1998) Article DOI: 10.1021/jm980398y BindingDB Entry DOI: 10.7270/Q2CC0XWN
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4060 (2-Amino-8-(3-benzyloxypropyl)-6-(2,6-dichloropheny...) Show SMILES Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(CCCOCc3ccccc3)c2n1 |(-6.98,-1.25,;-5.65,-.48,;-5.65,1.06,;-4.32,1.83,;-2.98,1.06,;-1.65,1.83,;-.32,1.06,;1.02,1.83,;1.02,3.37,;-.32,4.14,;2.35,4.14,;3.69,3.37,;3.69,1.83,;2.35,1.06,;2.35,-.48,;-.32,-.48,;1.02,-1.25,;-1.65,-1.25,;-1.65,-2.79,;-.32,-3.56,;-.32,-5.1,;1.02,-5.87,;1.02,-7.41,;2.35,-8.18,;2.35,-9.72,;3.69,-10.49,;5.02,-9.72,;5.02,-8.18,;3.69,-7.41,;-2.98,-.48,;-4.32,-1.25,)| Show InChI InChI=1S/C23H20Cl2N4O2/c24-18-8-4-9-19(25)20(18)17-12-16-13-27-23(26)28-21(16)29(22(17)30)10-5-11-31-14-15-6-2-1-3-7-15/h1-4,6-9,12-13H,5,10-11,14H2,(H2,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 41: 4365-77 (1998) Article DOI: 10.1021/jm980398y BindingDB Entry DOI: 10.7270/Q2CC0XWN
					More data for this Ligand-Target Pair