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SMILES: Cn1c2nc(Nc3ccncc3)ncc2cc(-c2ccsc2)c1=O

InChI Key: InChIKey=JYVVCQGPOZGXIP-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4066   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM4066 (8-Methyl-2-(pyridin-4-ylamino)-6-thiophene-3-yl-8H...) Show SMILES Cn1c2nc(Nc3ccncc3)ncc2cc(-c2ccsc2)c1=O Show InChI InChI=1S/C17H13N5OS/c1-22-15-12(8-14(16(22)23)11-4-7-24-10-11)9-19-17(21-15)20-13-2-5-18-6-3-13/h2-10H,1H3,(H,18,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 41: 4365-77 (1998) Article DOI: 10.1021/jm980398y BindingDB Entry DOI: 10.7270/Q2CC0XWN
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4066 (8-Methyl-2-(pyridin-4-ylamino)-6-thiophene-3-yl-8H...) Show SMILES Cn1c2nc(Nc3ccncc3)ncc2cc(-c2ccsc2)c1=O Show InChI InChI=1S/C17H13N5OS/c1-22-15-12(8-14(16(22)23)11-4-7-24-10-11)9-19-17(21-15)20-13-2-5-18-6-3-13/h2-10H,1H3,(H,18,19,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 41: 4365-77 (1998) Article DOI: 10.1021/jm980398y BindingDB Entry DOI: 10.7270/Q2CC0XWN
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4066 (8-Methyl-2-(pyridin-4-ylamino)-6-thiophene-3-yl-8H...) Show SMILES Cn1c2nc(Nc3ccncc3)ncc2cc(-c2ccsc2)c1=O Show InChI InChI=1S/C17H13N5OS/c1-22-15-12(8-14(16(22)23)11-4-7-24-10-11)9-19-17(21-15)20-13-2-5-18-6-3-13/h2-10H,1H3,(H,18,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.26E+4	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 41: 4365-77 (1998) Article DOI: 10.1021/jm980398y BindingDB Entry DOI: 10.7270/Q2CC0XWN
					More data for this Ligand-Target Pair