Found 117 hits for monomerid = 4078 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
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| Article PubMed
| n/a | n/a | 1.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Westf£lische Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CDK4/CyclinD1 expressed in Sf9 cells using RB-CTF as substrate after 80 mins by scintillation counting |
Bioorg Med Chem 20: 2282-9 (2012)
Article DOI: 10.1016/j.bmc.2012.02.017 BindingDB Entry DOI: 10.7270/Q2J966T6 |
More data for this Ligand-Target Pair | |
Insulin receptor
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
KEGG
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Westf£lische Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Inhibition of human recombinant INS-R expressed in Sf9 cells using poly(A,E,K,Y)6:2:5:1 as substrate after 80 mins by scintillation counting |
Bioorg Med Chem 20: 2282-9 (2012)
Article DOI: 10.1016/j.bmc.2012.02.017 BindingDB Entry DOI: 10.7270/Q2J966T6 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lyn
(Rattus norvegicus) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Padova
Curated by ChEMBL
| Assay Description Inhibition of rat spleen Lyn |
J Med Chem 49: 2363-6 (2006)
Article DOI: 10.1021/jm060112m BindingDB Entry DOI: 10.7270/Q2ZP45RN |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
KEGG
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Padova
Curated by ChEMBL
| Assay Description Inhibition of RET |
J Med Chem 49: 2363-6 (2006)
Article DOI: 10.1021/jm060112m BindingDB Entry DOI: 10.7270/Q2ZP45RN |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Padova
Curated by ChEMBL
| Assay Description Inhibition of FLT3 |
J Med Chem 49: 2363-6 (2006)
Article DOI: 10.1021/jm060112m BindingDB Entry DOI: 10.7270/Q2ZP45RN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Rattus norvegicus) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Padova
Curated by ChEMBL
| Assay Description Inhibition of rat spleen SYK |
J Med Chem 49: 2363-6 (2006)
Article DOI: 10.1021/jm060112m BindingDB Entry DOI: 10.7270/Q2ZP45RN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Fgr
(Rattus norvegicus) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
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| Article PubMed
| n/a | n/a | 9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Padova
Curated by ChEMBL
| Assay Description Inhibition of rat spleen FGR |
J Med Chem 49: 2363-6 (2006)
Article DOI: 10.1021/jm060112m BindingDB Entry DOI: 10.7270/Q2ZP45RN |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Padova
Curated by ChEMBL
| Assay Description Inhibition of human recombinant DYRK1a |
J Med Chem 49: 2363-6 (2006)
Article DOI: 10.1021/jm060112m BindingDB Entry DOI: 10.7270/Q2ZP45RN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase CSK
(Rattus norvegicus) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Padova
Curated by ChEMBL
| Assay Description Inhibition of rat spleen CSK |
J Med Chem 49: 2363-6 (2006)
Article DOI: 10.1021/jm060112m BindingDB Entry DOI: 10.7270/Q2ZP45RN |
More data for this Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 7.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Padova
Curated by ChEMBL
| Assay Description Inhibition of human recombinant GSK3-beta |
J Med Chem 49: 2363-6 (2006)
Article DOI: 10.1021/jm060112m BindingDB Entry DOI: 10.7270/Q2ZP45RN |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB
UniProtKB/SwissProt
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| PDB Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Osaka Prefecture University
Curated by ChEMBL
| Assay Description Inhibition of GST-fused human recombinant CK2alpha expressed in Escherichia coli HMS174 (DE3) |
Bioorg Med Chem Lett 19: 2920-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.076 BindingDB Entry DOI: 10.7270/Q25B02CC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | 7.71E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Justus-Liebig-University
Curated by ChEMBL
| Assay Description Inhibition of human glutathione S-transferase P |
Antimicrob Agents Chemother 53: 622-30 (2009)
Article DOI: 10.1128/AAC.00544-08 BindingDB Entry DOI: 10.7270/Q2RR1ZJ5 |
More data for this Ligand-Target Pair | |
Glutathione S-transferase
(Plasmodium falciparum) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 7.44E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Justus-Liebig-University
Curated by ChEMBL
| Assay Description Inhibition of Plasmodium falciparum glutathione S-transferase |
Antimicrob Agents Chemother 53: 622-30 (2009)
Article DOI: 10.1128/AAC.00544-08 BindingDB Entry DOI: 10.7270/Q2RR1ZJ5 |
More data for this Ligand-Target Pair | |
Glutathione reductase, mitochondrial
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | 2.28E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Justus-Liebig-University
Curated by ChEMBL
| Assay Description Inhibition of human glutathione reductase by spectrophotometer |
Antimicrob Agents Chemother 53: 622-30 (2009)
Article DOI: 10.1128/AAC.00544-08 BindingDB Entry DOI: 10.7270/Q2RR1ZJ5 |
More data for this Ligand-Target Pair | |
Aldo-keto reductase family 1 member B1
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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Patents
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| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
King's College London
Curated by ChEMBL
| Assay Description Inhibition of human recombinant aldose reductase using D-glyceraldehyde as substrate preincubated for 10 mins before substrate addition measured for ... |
Bioorg Med Chem 20: 1251-8 (2012)
Article DOI: 10.1016/j.bmc.2011.12.033 BindingDB Entry DOI: 10.7270/Q2639Q5V |
More data for this Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | 3.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Westf£lische Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Inhibition of human recombinant AKT1 expressed in Sf9 cells using GSK3(14-27) as substrate after 80 mins by scintillation counting |
Bioorg Med Chem 20: 2282-9 (2012)
Article DOI: 10.1016/j.bmc.2012.02.017 BindingDB Entry DOI: 10.7270/Q2J966T6 |
More data for this Ligand-Target Pair | |
NUAK family SNF1-like kinase 1
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | KEGG
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
Westf£lische Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Inhibition of human recombinant ARK5 expressed in Sf9 cells assessed as autophosphorylation after 80 mins by scintillation counting |
Bioorg Med Chem 20: 2282-9 (2012)
Article DOI: 10.1016/j.bmc.2012.02.017 BindingDB Entry DOI: 10.7270/Q2J966T6 |
More data for this Ligand-Target Pair | |
Aurora kinase A
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 2.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Westf£lische Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Inhibition of human recombinant aurora-A expressed in Sf9 cells using tetra(LRRWSLG) as substrate after 80 mins by scintillation counting |
Bioorg Med Chem 20: 2282-9 (2012)
Article DOI: 10.1016/j.bmc.2012.02.017 BindingDB Entry DOI: 10.7270/Q2J966T6 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | 1.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Westf£lische Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Inhibition of human recombinant B-RAF expressed in Sf9 cells using MEK1 KM as substrate after 80 mins by scintillation counting |
Bioorg Med Chem 20: 2282-9 (2012)
Article DOI: 10.1016/j.bmc.2012.02.017 BindingDB Entry DOI: 10.7270/Q2J966T6 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
KEGG
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | 690 | n/a | n/a | n/a | n/a | n/a | n/a |
Westf£lische Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Inhibition of human recombinant EGF-R expressed in Sf9 cells using poly(E,Y)4:1 as substrate after 80 mins by scintillation counting |
Bioorg Med Chem 20: 2282-9 (2012)
Article DOI: 10.1016/j.bmc.2012.02.017 BindingDB Entry DOI: 10.7270/Q2J966T6 |
More data for this Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | 1.83E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Westf£lische Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Inhibition of human recombinant EPHB4 expressed in Sf9 cells using poly(E,Y)4:1 as substrate after 80 mins by scintillation counting |
Bioorg Med Chem 20: 2282-9 (2012)
Article DOI: 10.1016/j.bmc.2012.02.017 BindingDB Entry DOI: 10.7270/Q2J966T6 |
More data for this Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | 3.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Westf£lische Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Inhibition of human recombinant ERBB2 expressed in Sf9 cells using poly(E,Y)4:1 as substrate after 80 mins by scintillation counting |
Bioorg Med Chem 20: 2282-9 (2012)
Article DOI: 10.1016/j.bmc.2012.02.017 BindingDB Entry DOI: 10.7270/Q2J966T6 |
More data for this Ligand-Target Pair | |
Focal adhesion kinase 1
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 3.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Westf£lische Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Inhibition of human recombinant FAK expressed in Sf9 cells using poly(E,Y)4:1 as substrate after 80 mins by scintillation counting |
Bioorg Med Chem 20: 2282-9 (2012)
Article DOI: 10.1016/j.bmc.2012.02.017 BindingDB Entry DOI: 10.7270/Q2J966T6 |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Westf£lische Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Inhibition of human recombinant IGF1R expressed in Sf9 cells using poly(E,Y)4:1 as substrate after 80 mins by scintillation counting |
Bioorg Med Chem 20: 2282-9 (2012)
Article DOI: 10.1016/j.bmc.2012.02.017 BindingDB Entry DOI: 10.7270/Q2J966T6 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
KEGG
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| Article PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Westf£lische Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Inhibition of human recombinant SRC expressed in Sf9 cells using poly(E,Y)4:1 as substrate after 80 mins by scintillation counting |
Bioorg Med Chem 20: 2282-9 (2012)
Article DOI: 10.1016/j.bmc.2012.02.017 BindingDB Entry DOI: 10.7270/Q2J966T6 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | 790 | n/a | n/a | n/a | n/a | n/a | n/a |
Westf£lische Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Inhibition of human recombinant VEGF-R2 expressed in Sf9 cells using poly(E,Y)4:1 as substrate after 80 mins by scintillation counting |
Bioorg Med Chem 20: 2282-9 (2012)
Article DOI: 10.1016/j.bmc.2012.02.017 BindingDB Entry DOI: 10.7270/Q2J966T6 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 3
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB
KEGG
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| n/a | n/a | 1.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Westf£lische Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Inhibition of human recombinant VEGF-R3 expressed in Sf9 cells using poly(E,Y)4:1 as substrate after 80 mins by scintillation counting |
Bioorg Med Chem 20: 2282-9 (2012)
Article DOI: 10.1016/j.bmc.2012.02.017 BindingDB Entry DOI: 10.7270/Q2J966T6 |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
KEGG
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| Article PubMed
| n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
Westf£lische Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MET expressed in Sf9 cells using poly(A,E,K,Y)6:2:5:1 as substrate after 80 mins by scintillation counting |
Bioorg Med Chem 20: 2282-9 (2012)
Article DOI: 10.1016/j.bmc.2012.02.017 BindingDB Entry DOI: 10.7270/Q2J966T6 |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
NCI pathway Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Westf£lische Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta expressed in Sf9 cells using poly(A,E,K,Y)6:2:5:1 as substrate after 80 mins by scintillation counting |
Bioorg Med Chem 20: 2282-9 (2012)
Article DOI: 10.1016/j.bmc.2012.02.017 BindingDB Entry DOI: 10.7270/Q2J966T6 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
NCI pathway Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 3.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Westf£lische Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PLK1 expressed in Sf9 cells using casein as substrate after 80 mins by scintillation counting |
Bioorg Med Chem 20: 2282-9 (2012)
Article DOI: 10.1016/j.bmc.2012.02.017 BindingDB Entry DOI: 10.7270/Q2J966T6 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK4
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
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| Article PubMed
| n/a | n/a | 2.97E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Westf£lische Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Inhibition of human recombinant SAK expressed in Sf9 cells using p38alpha-KRKR as substrate after 80 mins by scintillation counting |
Bioorg Med Chem 20: 2282-9 (2012)
Article DOI: 10.1016/j.bmc.2012.02.017 BindingDB Entry DOI: 10.7270/Q2J966T6 |
More data for this Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
KEGG
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| Article PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Westf£lische Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Inhibition of human recombinant TIE2 expressed in Sf9 cells using poly(E,Y)4:1 as substrate after 80 mins by scintillation counting |
Bioorg Med Chem 20: 2282-9 (2012)
Article DOI: 10.1016/j.bmc.2012.02.017 BindingDB Entry DOI: 10.7270/Q2J966T6 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 8
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | 2.37E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Westf£lische Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Inhibition of human recombinant COT expressed in Sf9 cells assessed as autophosphorylation after 80 mins by scintillation counting |
Bioorg Med Chem 20: 2282-9 (2012)
Article DOI: 10.1016/j.bmc.2012.02.017 BindingDB Entry DOI: 10.7270/Q2J966T6 |
More data for this Ligand-Target Pair | |
Integrase
(Human immunodeficiency virus 1) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
UniProtKB/TrEMBL
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| n/a | n/a | 5.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing |
J Med Chem 43: 2100-14 (2000)
BindingDB Entry DOI: 10.7270/Q27D2VTS |
More data for this Ligand-Target Pair | |
Cysteine protease ATG4B
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
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| Article PubMed
| n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp
Curated by ChEMBL
| Assay Description Inhibition of wild type recombinant Atg4B (unknown origin) expressed in Escherichia coli BL21 DE3 using N-terminal His6-tagged LC3B-PLA2 as substrate... |
Eur J Med Chem 123: 631-638 (2016)
Article DOI: 10.1016/j.ejmech.2016.07.073 BindingDB Entry DOI: 10.7270/Q2FT8P1P |
More data for this Ligand-Target Pair | |
DNA polymerase eta
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
Reactome pathway KEGG
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| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut Health Center
Curated by ChEMBL
| Assay Description Inhibition of human recombinant DNA polymerase eta expressed in Baculovirus expression system using TAMRA/BHQ-2-labeled primer/template measured at 2... |
J Med Chem 59: 9321-9336 (2016)
BindingDB Entry DOI: 10.7270/Q2ZC84TJ |
More data for this Ligand-Target Pair | |
DNA polymerase iota
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB
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| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut Health Center
Curated by ChEMBL
| Assay Description Inhibition of human recombinant DNA polymerase iota expressed in Baculovirus expression system using TAMRA/BHQ-2-labeled primer/template measured at ... |
J Med Chem 59: 9321-9336 (2016)
BindingDB Entry DOI: 10.7270/Q2ZC84TJ |
More data for this Ligand-Target Pair | |
Cruzipain
(Trypanosoma cruzi) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
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| Article PubMed
| n/a | n/a | 2.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California San Francisco
Curated by ChEMBL
| Assay Description Inhibition of cruzain in presence of 0.01% Triton X-100 |
J Med Chem 51: 2502-11 (2008)
Article DOI: 10.1021/jm701500e BindingDB Entry DOI: 10.7270/Q23R0TQG |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
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| n/a | n/a | 1.55E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
R.W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of DNA gyrase supercoiling in Escherichia coli. |
Bioorg Med Chem Lett 8: 97-100 (1998)
BindingDB Entry DOI: 10.7270/Q25141DT |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 6
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of South Carolina
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of ochratoxin A uptake (ochratoxin A / 1uM) in Xenopus laevis oocytes |
Drug Metab Dispos 33: 1097-100 (2005)
Article DOI: 10.1124/dmd.105.004275 BindingDB Entry DOI: 10.7270/Q2H13391 |
More data for this Ligand-Target Pair | |
Squalene monooxygenase
(Rattus norvegicus) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | Reactome pathway KEGG
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| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Shizuoka
Curated by ChEMBL
| Assay Description Inhibition of C-terminal hexahistidine-tagged rat recombinant squalene epoxidase without N-terminal putative membrane domain expressed in Escherichia... |
J Nat Prod 64: 1010-4 (2001)
BindingDB Entry DOI: 10.7270/Q25Q4X03 |
More data for this Ligand-Target Pair | |
Angiotensin-converting enzyme
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
Reactome pathway KEGG
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| n/a | n/a | 5.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of ACE by fluorometric assay |
J Nat Prod 51: 357-359 (1988)
Article DOI: 10.1021/np50056a033 BindingDB Entry DOI: 10.7270/Q2XW4M1C |
More data for this Ligand-Target Pair | |
G-protein coupled receptor 35
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB
KEGG
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| Article PubMed
| n/a | n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay |
ACS Med Chem Lett 3: 165-169 (2012)
Article DOI: 10.1021/ml2003058 BindingDB Entry DOI: 10.7270/Q2DB82W9 |
More data for this Ligand-Target Pair | |
G-protein coupled receptor 35
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB
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| n/a | n/a | n/a | n/a | 2.96E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactmas... |
ACS Med Chem Lett 3: 165-169 (2012)
Article DOI: 10.1021/ml2003058 BindingDB Entry DOI: 10.7270/Q2DB82W9 |
More data for this Ligand-Target Pair | |
G-protein coupled receptor 35
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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Patents
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 mins |
ACS Med Chem Lett 3: 165-169 (2012)
Article DOI: 10.1021/ml2003058 BindingDB Entry DOI: 10.7270/Q2DB82W9 |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
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| | n/a | n/a | 1.09E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description In vitro antibacterial activity was determined as inhibitory concentration causing 50% DNA-gyrase supercoiling inhibition (SCI) |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2FX7CM7 |
More data for this Ligand-Target Pair | |
ELAV-like protein 3
(Homo sapiens) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pavia
Curated by ChEMBL
| Assay Description Inhibition of ELAV3 (unknown origin)-artificial ARE complex formation after 30 mins in the presence of biotin-labeled RNA probe by chemiluminescence ... |
J Med Chem 60: 8257-8267 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01871 BindingDB Entry DOI: 10.7270/Q2377BWD |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.77E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MIF expressed in Escherichia coli BL21(DE3) using dopa as substrate |
J Med Chem 61: 8104-8119 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00589 BindingDB Entry DOI: 10.7270/Q2KS6V5P |
More data for this Ligand-Target Pair | |
Reverse transcriptase
(Human immunodeficiency virus 1) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
UniProtKB/TrEMBL
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Patents
Similars
| Article PubMed
| n/a | n/a | <4.96E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois
Curated by ChEMBL
| Assay Description Inhibition of HIV1 RT |
J Nat Prod 54: 143-54
Article DOI: 10.1021/np50073a012 BindingDB Entry DOI: 10.7270/Q2NK3HTG |
More data for this Ligand-Target Pair | |
Aldo-keto reductase family 1 member B1
(Rattus norvegicus) | BDBM4078
(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)Show InChI InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
Similars
| Article
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of Rattus norvegicus (rat) lens aldose reductase |
Citation and Details
Article DOI: 10.1007/s00044-011-9681-6 BindingDB Entry DOI: 10.7270/Q2J1061V |
More data for this Ligand-Target Pair | |