BDBM4172 1,6-naphthyridin-2(1H)-one deriv. 7e::3-(2,6-Dichlorophenyl)-7-[[3-(diethylamino)propyl]amino]-1-methyl-1,6-naphthyridin-2(1H)-one::3-(2,6-dichlorophenyl)-7-{[3-(diethylamino)propyl]amino}-1-methyl-1,2-dihydro-1,6-naphthyridin-2-one
SMILES: CCN(CC)CCCNc1cc2n(C)c(=O)c(cc2cn1)-c1c(Cl)cccc1Cl
InChI Key: InChIKey=DHTNVMBSGAPRGN-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM4172 (1,6-naphthyridin-2(1H)-one deriv. 7e | 3-(2,6-Dich...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | 7.0 | 25 |
University of Auckland | Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe... | J Med Chem 43: 3134-47 (2000) Article DOI: 10.1021/jm000148t BindingDB Entry DOI: 10.7270/Q2028PQ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM4172 (1,6-naphthyridin-2(1H)-one deriv. 7e | 3-(2,6-Dich...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | 7.5 | 22 |
University of Auckland | Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe... | J Med Chem 43: 3134-47 (2000) Article DOI: 10.1021/jm000148t BindingDB Entry DOI: 10.7270/Q2028PQ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 1 (Homo sapiens (Human)) | BDBM4172 (1,6-naphthyridin-2(1H)-one deriv. 7e | 3-(2,6-Dich...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | 7.0 | 25 |
University of Auckland | Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe... | J Med Chem 43: 3134-47 (2000) Article DOI: 10.1021/jm000148t BindingDB Entry DOI: 10.7270/Q2028PQ1 | |||||||||||
More data for this Ligand-Target Pair |