BDBM4176 1,6-naphthyridin-2(1H)-one deriv. 7i::3-(2,6-Dichlorophenyl)-1-methyl-7-[[4-(4-methylpiperazin-1-yl)butyl]amino]-1,6-naphthyridin-2(1H)-one::3-(2,6-dichlorophenyl)-1-methyl-7-{[4-(4-methylpiperazin-1-yl)butyl]amino}-1,2-dihydro-1,6-naphthyridin-2-one

SMILES: CN1CCN(CCCCNc2cc3n(C)c(=O)c(cc3cn2)-c2c(Cl)cccc2Cl)CC1

InChI Key: InChIKey=LXTVIIYXNZBKDS-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4176   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM4176 (1,6-naphthyridin-2(1H)-one deriv. 7i | 3-(2,6-Dich...) Show SMILES CN1CCN(CCCCNc2cc3n(C)c(=O)c(cc3cn2)-c2c(Cl)cccc2Cl)CC1 |(-17.31,.81,;-15.82,.41,;-14.47,1.16,;-13.16,.36,;-13.19,-1.18,;-11.85,-1.95,;-10.52,-1.18,;-9.18,-1.95,;-7.85,-1.18,;-6.52,-1.95,;-5.18,-1.18,;-3.85,-1.95,;-2.52,-1.12,;-1.18,-1.89,;-1.18,-3.43,;.15,-1.12,;1.48,-1.89,;.15,.42,;-1.18,1.19,;-2.52,.42,;-3.85,1.13,;-5.18,.36,;1.48,1.19,;1.48,2.73,;.15,3.5,;2.82,3.5,;4.15,2.73,;4.15,1.19,;2.82,.42,;2.82,-1.12,;-14.53,-1.92,;-15.85,-1.13,)| Show InChI InChI=1S/C24H29Cl2N5O/c1-29-10-12-31(13-11-29)9-4-3-8-27-22-15-21-17(16-28-22)14-18(24(32)30(21)2)23-19(25)6-5-7-20(23)26/h5-7,14-16H,3-4,8-13H2,1-2H3,(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 43: 3134-47 (2000) Article DOI: 10.1021/jm000148t BindingDB Entry DOI: 10.7270/Q2028PQ1
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4176 (1,6-naphthyridin-2(1H)-one deriv. 7i | 3-(2,6-Dich...) Show SMILES CN1CCN(CCCCNc2cc3n(C)c(=O)c(cc3cn2)-c2c(Cl)cccc2Cl)CC1 |(-17.31,.81,;-15.82,.41,;-14.47,1.16,;-13.16,.36,;-13.19,-1.18,;-11.85,-1.95,;-10.52,-1.18,;-9.18,-1.95,;-7.85,-1.18,;-6.52,-1.95,;-5.18,-1.18,;-3.85,-1.95,;-2.52,-1.12,;-1.18,-1.89,;-1.18,-3.43,;.15,-1.12,;1.48,-1.89,;.15,.42,;-1.18,1.19,;-2.52,.42,;-3.85,1.13,;-5.18,.36,;1.48,1.19,;1.48,2.73,;.15,3.5,;2.82,3.5,;4.15,2.73,;4.15,1.19,;2.82,.42,;2.82,-1.12,;-14.53,-1.92,;-15.85,-1.13,)| Show InChI InChI=1S/C24H29Cl2N5O/c1-29-10-12-31(13-11-29)9-4-3-8-27-22-15-21-17(16-28-22)14-18(24(32)30(21)2)23-19(25)6-5-7-20(23)26/h5-7,14-16H,3-4,8-13H2,1-2H3,(H,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 43: 3134-47 (2000) Article DOI: 10.1021/jm000148t BindingDB Entry DOI: 10.7270/Q2028PQ1
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4176 (1,6-naphthyridin-2(1H)-one deriv. 7i | 3-(2,6-Dich...) Show SMILES CN1CCN(CCCCNc2cc3n(C)c(=O)c(cc3cn2)-c2c(Cl)cccc2Cl)CC1 |(-17.31,.81,;-15.82,.41,;-14.47,1.16,;-13.16,.36,;-13.19,-1.18,;-11.85,-1.95,;-10.52,-1.18,;-9.18,-1.95,;-7.85,-1.18,;-6.52,-1.95,;-5.18,-1.18,;-3.85,-1.95,;-2.52,-1.12,;-1.18,-1.89,;-1.18,-3.43,;.15,-1.12,;1.48,-1.89,;.15,.42,;-1.18,1.19,;-2.52,.42,;-3.85,1.13,;-5.18,.36,;1.48,1.19,;1.48,2.73,;.15,3.5,;2.82,3.5,;4.15,2.73,;4.15,1.19,;2.82,.42,;2.82,-1.12,;-14.53,-1.92,;-15.85,-1.13,)| Show InChI InChI=1S/C24H29Cl2N5O/c1-29-10-12-31(13-11-29)9-4-3-8-27-22-15-21-17(16-28-22)14-18(24(32)30(21)2)23-19(25)6-5-7-20(23)26/h5-7,14-16H,3-4,8-13H2,1-2H3,(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 43: 3134-47 (2000) Article DOI: 10.1021/jm000148t BindingDB Entry DOI: 10.7270/Q2028PQ1
					More data for this Ligand-Target Pair