BDBM4189 1,6-naphthyridin-2(1H)-one deriv. 7v::3-(2,6-Dichlorophenyl)-1-methyl-7-[[4-(4-morpholino)-phenyl]amino]-1,6-naphthyridin-2(1H)-one::3-(2,6-dichlorophenyl)-1-methyl-7-{[4-(morpholin-4-yl)phenyl]amino}-1,2-dihydro-1,6-naphthyridin-2-one

SMILES: Cn1c2cc(Nc3ccc(cc3)N3CCOCC3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O

InChI Key: InChIKey=GWHOPAUAFXUMEC-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4189   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM4189 (1,6-naphthyridin-2(1H)-one deriv. 7v | 3-(2,6-Dich...) Show SMILES Cn1c2cc(Nc3ccc(cc3)N3CCOCC3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-1.18,-3.43,;-1.18,-1.89,;-2.52,-1.12,;-3.85,-1.95,;-5.18,-1.18,;-6.52,-1.95,;-7.85,-1.18,;-9.18,-1.95,;-10.52,-1.18,;-10.52,.36,;-9.18,1.13,;-7.85,.36,;-11.85,1.13,;-11.85,2.67,;-13.19,3.44,;-14.52,2.67,;-14.52,1.13,;-13.19,.36,;-5.18,.36,;-3.85,1.13,;-2.52,.42,;-1.18,1.19,;.15,.42,;1.48,1.19,;1.48,2.73,;.15,3.5,;2.82,3.5,;4.15,2.73,;4.15,1.19,;2.82,.42,;2.82,-1.12,;.15,-1.12,;1.48,-1.89,)| Show InChI InChI=1S/C25H22Cl2N4O2/c1-30-22-14-23(29-17-5-7-18(8-6-17)31-9-11-33-12-10-31)28-15-16(22)13-19(25(30)32)24-20(26)3-2-4-21(24)27/h2-8,13-15H,9-12H2,1H3,(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 43: 3134-47 (2000) Article DOI: 10.1021/jm000148t BindingDB Entry DOI: 10.7270/Q2028PQ1
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4189 (1,6-naphthyridin-2(1H)-one deriv. 7v | 3-(2,6-Dich...) Show SMILES Cn1c2cc(Nc3ccc(cc3)N3CCOCC3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-1.18,-3.43,;-1.18,-1.89,;-2.52,-1.12,;-3.85,-1.95,;-5.18,-1.18,;-6.52,-1.95,;-7.85,-1.18,;-9.18,-1.95,;-10.52,-1.18,;-10.52,.36,;-9.18,1.13,;-7.85,.36,;-11.85,1.13,;-11.85,2.67,;-13.19,3.44,;-14.52,2.67,;-14.52,1.13,;-13.19,.36,;-5.18,.36,;-3.85,1.13,;-2.52,.42,;-1.18,1.19,;.15,.42,;1.48,1.19,;1.48,2.73,;.15,3.5,;2.82,3.5,;4.15,2.73,;4.15,1.19,;2.82,.42,;2.82,-1.12,;.15,-1.12,;1.48,-1.89,)| Show InChI InChI=1S/C25H22Cl2N4O2/c1-30-22-14-23(29-17-5-7-18(8-6-17)31-9-11-33-12-10-31)28-15-16(22)13-19(25(30)32)24-20(26)3-2-4-21(24)27/h2-8,13-15H,9-12H2,1H3,(H,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 43: 3134-47 (2000) Article DOI: 10.1021/jm000148t BindingDB Entry DOI: 10.7270/Q2028PQ1
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4189 (1,6-naphthyridin-2(1H)-one deriv. 7v | 3-(2,6-Dich...) Show SMILES Cn1c2cc(Nc3ccc(cc3)N3CCOCC3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-1.18,-3.43,;-1.18,-1.89,;-2.52,-1.12,;-3.85,-1.95,;-5.18,-1.18,;-6.52,-1.95,;-7.85,-1.18,;-9.18,-1.95,;-10.52,-1.18,;-10.52,.36,;-9.18,1.13,;-7.85,.36,;-11.85,1.13,;-11.85,2.67,;-13.19,3.44,;-14.52,2.67,;-14.52,1.13,;-13.19,.36,;-5.18,.36,;-3.85,1.13,;-2.52,.42,;-1.18,1.19,;.15,.42,;1.48,1.19,;1.48,2.73,;.15,3.5,;2.82,3.5,;4.15,2.73,;4.15,1.19,;2.82,.42,;2.82,-1.12,;.15,-1.12,;1.48,-1.89,)| Show InChI InChI=1S/C25H22Cl2N4O2/c1-30-22-14-23(29-17-5-7-18(8-6-17)31-9-11-33-12-10-31)28-15-16(22)13-19(25(30)32)24-20(26)3-2-4-21(24)27/h2-8,13-15H,9-12H2,1H3,(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 43: 3134-47 (2000) Article DOI: 10.1021/jm000148t BindingDB Entry DOI: 10.7270/Q2028PQ1
					More data for this Ligand-Target Pair