BDBM4199 1,8-naphthyridin-2(1H)-one deriv. 9q::3-(2,6-Dichlorophenyl)-7-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-1-methyl-1,8-naphthyridin-2(1H)-one::3-(2,6-dichlorophenyl)-7-({4-[2-(diethylamino)ethoxy]phenyl}amino)-1-methyl-1,2-dihydro-1,8-naphthyridin-2-one

SMILES: CCN(CC)CCOc1ccc(Nc2ccc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1

InChI Key: InChIKey=ZKUIGFKRPUCRRC-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4199   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM4199 (1,8-naphthyridin-2(1H)-one deriv. 9q | 3-(2,6-Dich...) Show SMILES CCN(CC)CCOc1ccc(Nc2ccc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 |(-18.34,1.74,;-16.85,2.14,;-15.76,1.05,;-16.16,-.44,;-15.07,-1.52,;-14.27,1.45,;-13.19,.36,;-11.85,1.13,;-10.52,.36,;-10.52,-1.18,;-9.18,-1.95,;-7.85,-1.18,;-6.52,-1.95,;-5.18,-1.18,;-5.18,.36,;-3.85,1.13,;-2.52,.42,;-1.18,1.19,;.15,.42,;1.48,1.19,;1.48,2.73,;.15,3.5,;2.82,3.5,;4.15,2.73,;4.15,1.19,;2.82,.42,;2.82,-1.12,;.15,-1.12,;1.48,-1.89,;-1.18,-1.89,;-1.18,-3.43,;-2.52,-1.12,;-3.85,-1.95,;-7.85,.36,;-9.18,1.13,)| Show InChI InChI=1S/C27H28Cl2N4O2/c1-4-33(5-2)15-16-35-20-12-10-19(11-13-20)30-24-14-9-18-17-21(27(34)32(3)26(18)31-24)25-22(28)7-6-8-23(25)29/h6-14,17H,4-5,15-16H2,1-3H3,(H,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 43: 3134-47 (2000) Article DOI: 10.1021/jm000148t BindingDB Entry DOI: 10.7270/Q2028PQ1
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4199 (1,8-naphthyridin-2(1H)-one deriv. 9q | 3-(2,6-Dich...) Show SMILES CCN(CC)CCOc1ccc(Nc2ccc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 |(-18.34,1.74,;-16.85,2.14,;-15.76,1.05,;-16.16,-.44,;-15.07,-1.52,;-14.27,1.45,;-13.19,.36,;-11.85,1.13,;-10.52,.36,;-10.52,-1.18,;-9.18,-1.95,;-7.85,-1.18,;-6.52,-1.95,;-5.18,-1.18,;-5.18,.36,;-3.85,1.13,;-2.52,.42,;-1.18,1.19,;.15,.42,;1.48,1.19,;1.48,2.73,;.15,3.5,;2.82,3.5,;4.15,2.73,;4.15,1.19,;2.82,.42,;2.82,-1.12,;.15,-1.12,;1.48,-1.89,;-1.18,-1.89,;-1.18,-3.43,;-2.52,-1.12,;-3.85,-1.95,;-7.85,.36,;-9.18,1.13,)| Show InChI InChI=1S/C27H28Cl2N4O2/c1-4-33(5-2)15-16-35-20-12-10-19(11-13-20)30-24-14-9-18-17-21(27(34)32(3)26(18)31-24)25-22(28)7-6-8-23(25)29/h6-14,17H,4-5,15-16H2,1-3H3,(H,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 43: 3134-47 (2000) Article DOI: 10.1021/jm000148t BindingDB Entry DOI: 10.7270/Q2028PQ1
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4199 (1,8-naphthyridin-2(1H)-one deriv. 9q | 3-(2,6-Dich...) Show SMILES CCN(CC)CCOc1ccc(Nc2ccc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 |(-18.34,1.74,;-16.85,2.14,;-15.76,1.05,;-16.16,-.44,;-15.07,-1.52,;-14.27,1.45,;-13.19,.36,;-11.85,1.13,;-10.52,.36,;-10.52,-1.18,;-9.18,-1.95,;-7.85,-1.18,;-6.52,-1.95,;-5.18,-1.18,;-5.18,.36,;-3.85,1.13,;-2.52,.42,;-1.18,1.19,;.15,.42,;1.48,1.19,;1.48,2.73,;.15,3.5,;2.82,3.5,;4.15,2.73,;4.15,1.19,;2.82,.42,;2.82,-1.12,;.15,-1.12,;1.48,-1.89,;-1.18,-1.89,;-1.18,-3.43,;-2.52,-1.12,;-3.85,-1.95,;-7.85,.36,;-9.18,1.13,)| Show InChI InChI=1S/C27H28Cl2N4O2/c1-4-33(5-2)15-16-35-20-12-10-19(11-13-20)30-24-14-9-18-17-21(27(34)32(3)26(18)31-24)25-22(28)7-6-8-23(25)29/h6-14,17H,4-5,15-16H2,1-3H3,(H,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 43: 3134-47 (2000) Article DOI: 10.1021/jm000148t BindingDB Entry DOI: 10.7270/Q2028PQ1
					More data for this Ligand-Target Pair