BDBM4312 (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(2,4-dimethoxyphenyl)prop-2-enamide::Tyrphostin deriv. 64

SMILES: COc1ccc(NC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)c(OC)c1

InChI Key: InChIKey=CSHGVUBBAZPQSJ-KPKJPENVSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4312   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4312 ((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(2,4-dimeth...) Show SMILES COc1ccc(NC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)c(OC)c1 Show InChI InChI=1S/C18H16N2O5/c1-24-13-4-5-14(17(9-13)25-2)20-18(23)12(10-19)7-11-3-6-15(21)16(22)8-11/h3-9,21-22H,1-2H3,(H,20,23)/b12-7+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hebrew University of Jerusalem					Assay Description The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.				J Med Chem 34: 1896-907 (1991) Article DOI: 10.1021/jm00110a022 BindingDB Entry DOI: 10.7270/Q2KW5D7V
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM4312 ((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(2,4-dimeth...) Show SMILES COc1ccc(NC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)c(OC)c1 Show InChI InChI=1S/C18H16N2O5/c1-24-13-4-5-14(17(9-13)25-2)20-18(23)12(10-19)7-11-3-6-15(21)16(22)8-11/h3-9,21-22H,1-2H3,(H,20,23)/b12-7+	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.66E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Tennessee Health Sciences Center Curated by ChEMBL					Assay Description Inhibitory activity tested against protein kinase HER-2				J Med Chem 46: 4657-68 (2003) Article DOI: 10.1021/jm030065n BindingDB Entry DOI: 10.7270/Q2N58NKR
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4312 ((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(2,4-dimeth...) Show SMILES COc1ccc(NC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)c(OC)c1 Show InChI InChI=1S/C18H16N2O5/c1-24-13-4-5-14(17(9-13)25-2)20-18(23)12(10-19)7-11-3-6-15(21)16(22)8-11/h3-9,21-22H,1-2H3,(H,20,23)/b12-7+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.51E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Tennessee Health Sciences Center Curated by ChEMBL					Assay Description Inhibitory activity against epidermal growth factor receptor (EGFR)				J Med Chem 46: 4657-68 (2003) Article DOI: 10.1021/jm030065n BindingDB Entry DOI: 10.7270/Q2N58NKR
					More data for this Ligand-Target Pair