BDBM4318 2-[(3,5-dimethoxyphenyl)methylidene]propanedinitrile::benzylidenemalononitrile (BMN) deriv. 2
SMILES: [#6]-[#8]-c1cc(-[#8]-[#6])cc(\[#6]=[#6](/C#N)C#N)c1
InChI Key: InChIKey=YAYKQTPCKRWLAP-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM4318 (2-[(3,5-dimethoxyphenyl)methylidene]propanedinitri...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | >4.00E+5 | >-4.59 | >1.25E+6 | n/a | n/a | n/a | n/a | 7.6 | 22 |
Hebrew University of Jerusalem | Assay Description The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate. | J Med Chem 32: 2344-52 (1989) Article DOI: 10.1021/jm00130a020 BindingDB Entry DOI: 10.7270/Q2G44NHF | |||||||||||
More data for this Ligand-Target Pair |