BDBM4320 2-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]propanedinitrile::benzylidenemalononitrile (BMN) deriv. 4
SMILES: [#6]-[#8]-c1cc(\[#6]=[#6](/C#N)C#N)cc(-[#8]-[#6])c1-[#8]
InChI Key: InChIKey=ZEGOLZJKCSVYBM-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM4320 (2-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]prop...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 3.00E+5 | -4.75 | 8.50E+5 | n/a | n/a | n/a | n/a | 7.6 | 22 |
Hebrew University of Jerusalem | Assay Description The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate. | J Med Chem 32: 2344-52 (1989) Article DOI: 10.1021/jm00130a020 BindingDB Entry DOI: 10.7270/Q2G44NHF | |||||||||||
More data for this Ligand-Target Pair |