BDBM4343 (2E)-2-cyano-3-(4-methoxyphenyl)prop-2-enoic acid::benzylidenemalononitrile (BMN) deriv. 27
SMILES: COc1ccc(\C=C(/C#N)C(O)=O)cc1
InChI Key: InChIKey=KMHNRJDDHTZZDZ-RMKNXTFCSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM4343 ((2E)-2-cyano-3-(4-methoxyphenyl)prop-2-enoic acid ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | 8.33E+5 | n/a | 2.50E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Hebrew University of Jerusalem | Assay Description The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate. | J Med Chem 32: 2344-52 (1989) Article DOI: 10.1021/jm00130a020 BindingDB Entry DOI: 10.7270/Q2G44NHF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monocarboxylate transporter 1 (MCT1) (Rattus norvegicus (Rat)) | BDBM4343 ((2E)-2-cyano-3-(4-methoxyphenyl)prop-2-enoic acid ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Medical School Duluth Curated by ChEMBL | Assay Description Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay | ACS Med Chem Lett 6: 558-61 (2015) Article DOI: 10.1021/acsmedchemlett.5b00049 BindingDB Entry DOI: 10.7270/Q2ZC84MV | |||||||||||
More data for this Ligand-Target Pair |