Found 7 hits for monomerid = 4367 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM4367
((3Z)-2-amino-3-[(3,4,5-trihydroxyphenyl)methyliden...)Show SMILES Oc1cc(C=C(C#N)C(=N)C(C#N)C#N)cc(O)c1O |w:4.3| Show InChI InChI=1S/C13H8N4O3/c14-4-8(12(17)9(5-15)6-16)1-7-2-10(18)13(20)11(19)3-7/h1-3,9,17-20H | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Hebrew University of Jerusalem
| Assay Description The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate. |
J Med Chem 32: 2344-52 (1989)
Article DOI: 10.1021/jm00130a020 BindingDB Entry DOI: 10.7270/Q2G44NHF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM4367
((3Z)-2-amino-3-[(3,4,5-trihydroxyphenyl)methyliden...)Show SMILES Oc1cc(C=C(C#N)C(=N)C(C#N)C#N)cc(O)c1O |w:4.3| Show InChI InChI=1S/C13H8N4O3/c14-4-8(12(17)9(5-15)6-16)1-7-2-10(18)13(20)11(19)3-7/h1-3,9,17-20H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Research Institute of Chemical Technology
Curated by ChEMBL
| Assay Description Inhibitory activity against FGFR1 kinase |
Bioorg Med Chem Lett 16: 737-42 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.115 BindingDB Entry DOI: 10.7270/Q2SF2VQR |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM4367
((3Z)-2-amino-3-[(3,4,5-trihydroxyphenyl)methyliden...)Show SMILES Oc1cc(C=C(C#N)C(=N)C(C#N)C#N)cc(O)c1O |w:4.3| Show InChI InChI=1S/C13H8N4O3/c14-4-8(12(17)9(5-15)6-16)1-7-2-10(18)13(20)11(19)3-7/h1-3,9,17-20H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Research Institute of Chemical Technology
Curated by ChEMBL
| Assay Description Inhibitory activity against VEGFR2 kinase |
Bioorg Med Chem Lett 16: 737-42 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.115 BindingDB Entry DOI: 10.7270/Q2SF2VQR |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM4367
((3Z)-2-amino-3-[(3,4,5-trihydroxyphenyl)methyliden...)Show SMILES Oc1cc(C=C(C#N)C(=N)C(C#N)C#N)cc(O)c1O |w:4.3| Show InChI InChI=1S/C13H8N4O3/c14-4-8(12(17)9(5-15)6-16)1-7-2-10(18)13(20)11(19)3-7/h1-3,9,17-20H | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Molecular Physiology
Curated by ChEMBL
| Assay Description Inhibition of EGFR |
Bioorg Med Chem 17: 1079-87 (2009)
Article DOI: 10.1016/j.bmc.2008.02.046 BindingDB Entry DOI: 10.7270/Q2M046C4 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM4367
((3Z)-2-amino-3-[(3,4,5-trihydroxyphenyl)methyliden...)Show SMILES Oc1cc(C=C(C#N)C(=N)C(C#N)C#N)cc(O)c1O |w:4.3| Show InChI InChI=1S/C13H8N4O3/c14-4-8(12(17)9(5-15)6-16)1-7-2-10(18)13(20)11(19)3-7/h1-3,9,17-20H | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Research Institute of Chemical Technology
Curated by ChEMBL
| Assay Description Inhibitory activity against EGFR kinase |
Bioorg Med Chem Lett 16: 737-42 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.115 BindingDB Entry DOI: 10.7270/Q2SF2VQR |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM4367
((3Z)-2-amino-3-[(3,4,5-trihydroxyphenyl)methyliden...)Show SMILES Oc1cc(C=C(C#N)C(=N)C(C#N)C#N)cc(O)c1O |w:4.3| Show InChI InChI=1S/C13H8N4O3/c14-4-8(12(17)9(5-15)6-16)1-7-2-10(18)13(20)11(19)3-7/h1-3,9,17-20H | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of EGFR in human A431 cells |
J Nat Prod 55: 1529-1560 (1992)
Article DOI: 10.1021/np50089a001 BindingDB Entry DOI: 10.7270/Q2J966CC |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM4367
((3Z)-2-amino-3-[(3,4,5-trihydroxyphenyl)methyliden...)Show SMILES Oc1cc(C=C(C#N)C(=N)C(C#N)C#N)cc(O)c1O |w:4.3| Show InChI InChI=1S/C13H8N4O3/c14-4-8(12(17)9(5-15)6-16)1-7-2-10(18)13(20)11(19)3-7/h1-3,9,17-20H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Research Institute of Chemical Technology
Curated by ChEMBL
| Assay Description Inhibitory activity against PDGFRbeta kinase |
Bioorg Med Chem Lett 16: 737-42 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.115 BindingDB Entry DOI: 10.7270/Q2SF2VQR |
More data for this Ligand-Target Pair | |