BDBM4542 4-Phenylamino-3-quinolinecarbonitrile deriv. 2b::4-[(2-Chloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-morpholinyl)propoxy]-3-quinolinecarbonitrile::4-[(2-chloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinoline-3-carbonitrile
SMILES: COc1ccc(Cl)c(Nc2c(cnc3cc(OCCCN4CCOCC4)c(OC)cc23)C#N)c1
InChI Key: InChIKey=GJTWFSFZLIOXFD-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM4542 (4-Phenylamino-3-quinolinecarbonitrile deriv. 2b | ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Wyeth-Ayerst Research | Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra... | J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP | |||||||||||
More data for this Ligand-Target Pair |