BDBM4546 4-Phenylamino-3-quinolinecarbonitrile deriv. 2f::4-[(2,4-Dimethyl-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-morpholinyl)propoxy]-3-quinolinecarbonitrile::6-methoxy-4-[(5-methoxy-2,4-dimethylphenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinoline-3-carbonitrile
SMILES: COc1cc(Nc2c(cnc3cc(OCCCN4CCOCC4)c(OC)cc23)C#N)c(C)cc1C
InChI Key: InChIKey=HMQAQKDHRMARNF-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM4546 (4-Phenylamino-3-quinolinecarbonitrile deriv. 2f | ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research | Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra... | J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP | |||||||||||
More data for this Ligand-Target Pair |