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SMILES: COc1cc(OC)cc(c1)-c1cc2cnc(N)cc2nc1N

InChI Key: InChIKey=XXQRJTXNOCEQLF-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4610   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4610 (1,6-naphthyridine deriv. 12 | 3-(3,5-dimethoxyphen...) Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(N)cc2nc1N Show InChI InChI=1S/C16H16N4O2/c1-21-11-3-9(4-12(6-11)22-2)13-5-10-8-19-15(17)7-14(10)20-16(13)18/h3-8H,1-2H3,(H2,17,19)(H2,18,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	7.4	25
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 43: 4200-11 (2000) Article DOI: 10.1021/jm000161d BindingDB Entry DOI: 10.7270/Q2JW8C3G
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4610 (1,6-naphthyridine deriv. 12 | 3-(3,5-dimethoxyphen...) Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(N)cc2nc1N Show InChI InChI=1S/C16H16N4O2/c1-21-11-3-9(4-12(6-11)22-2)13-5-10-8-19-15(17)7-14(10)20-16(13)18/h3-8H,1-2H3,(H2,17,19)(H2,18,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 43: 4200-11 (2000) Article DOI: 10.1021/jm000161d BindingDB Entry DOI: 10.7270/Q2JW8C3G
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM4610 (1,6-naphthyridine deriv. 12 | 3-(3,5-dimethoxyphen...) Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(N)cc2nc1N Show InChI InChI=1S/C16H16N4O2/c1-21-11-3-9(4-12(6-11)22-2)13-5-10-8-19-15(17)7-14(10)20-16(13)18/h3-8H,1-2H3,(H2,17,19)(H2,18,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	7.4	25
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 43: 4200-11 (2000) Article DOI: 10.1021/jm000161d BindingDB Entry DOI: 10.7270/Q2JW8C3G
					More data for this Ligand-Target Pair