BDBM4632 Anilinoquinazoline deriv. 15::N-(4-Chloro-2-fluorophenyl)-7-(2-methoxyethoxy)-4-quinazolinylamine::N-(4-chloro-2-fluorophenyl)-7-(2-methoxyethoxy)quinazolin-4-amine

SMILES: COCCOc1ccc2c(Nc3ccc(Cl)cc3F)ncnc2c1

InChI Key: InChIKey=PMDSTJDYKPKKER-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4632   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM4632 (Anilinoquinazoline deriv. 15 | N-(4-Chloro-2-fluor...) Show SMILES COCCOc1ccc2c(Nc3ccc(Cl)cc3F)ncnc2c1 Show InChI InChI=1S/C17H15ClFN3O2/c1-23-6-7-24-12-3-4-13-16(9-12)20-10-21-17(13)22-15-5-2-11(18)8-14(15)19/h2-5,8-10H,6-7H2,1H3,(H,20,21,22)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	7.4	22
AstraZeneca					Assay Description An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...				J Med Chem 42: 5369-89 (1999) Article DOI: 10.1021/jm990345w BindingDB Entry DOI: 10.7270/Q2F47MBM
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4632 (Anilinoquinazoline deriv. 15 | N-(4-Chloro-2-fluor...) Show SMILES COCCOc1ccc2c(Nc3ccc(Cl)cc3F)ncnc2c1 Show InChI InChI=1S/C17H15ClFN3O2/c1-23-6-7-24-12-3-4-13-16(9-12)20-10-21-17(13)22-15-5-2-11(18)8-14(15)19/h2-5,8-10H,6-7H2,1H3,(H,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	25
AstraZeneca					Assay Description An ELISA assay was used to determine the ability of inhibitor to inhibit FGFR-1 TK activity. The compounds were incubated with enzyme 20 min at room ...				J Med Chem 42: 5369-89 (1999) Article DOI: 10.1021/jm990345w BindingDB Entry DOI: 10.7270/Q2F47MBM
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM4632 (Anilinoquinazoline deriv. 15 | N-(4-Chloro-2-fluor...) Show SMILES COCCOc1ccc2c(Nc3ccc(Cl)cc3F)ncnc2c1 Show InChI InChI=1S/C17H15ClFN3O2/c1-23-6-7-24-12-3-4-13-16(9-12)20-10-21-17(13)22-15-5-2-11(18)8-14(15)19/h2-5,8-10H,6-7H2,1H3,(H,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	25
AstraZeneca					Assay Description An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...				J Med Chem 42: 5369-89 (1999) Article DOI: 10.1021/jm990345w BindingDB Entry DOI: 10.7270/Q2F47MBM
					More data for this Ligand-Target Pair