BDBM4787 (2E)-N-[4-(3-Bromoanilino)pyrido[3,4-d]pyrimidin-6-yl]-2,4-pentadienamide::(2E)-N-{4-[(3-bromophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl}penta-2,4-dienamide::4-Anilinopyrido[3,4-d]pyrimidine 14

SMILES: Brc1cccc(Nc2ncnc3cnc(NC(=O)\C=C\C=C)cc23)c1

InChI Key: InChIKey=UHUXAMBAPFKPGQ-XVNBXDOJSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 4787   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4787 ((2E)-N-[4-(3-Bromoanilino)pyrido[3,4-d]pyrimidin-6...) Show SMILES Brc1cccc(Nc2ncnc3cnc(NC(=O)\C=C\C=C)cc23)c1 Show InChI InChI=1S/C18H14BrN5O/c1-2-3-7-17(25)24-16-9-14-15(10-20-16)21-11-22-18(14)23-13-6-4-5-12(19)8-13/h2-11H,1H2,(H,20,24,25)(H,21,22,23)/b7-3+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.4	25
University of Auckland					Assay Description Enzyme assays for IC50 determinations were performed in 96-well filter plates. IC50 is the inhibitor concentration which inhibits 50% of kinase activ...				J Med Chem 44: 429-40 (2001) Article DOI: 10.1021/jm000372i BindingDB Entry DOI: 10.7270/Q2HX19WB
					More data for this Ligand-Target Pair