BDBM4788 6-Substituted 4-Anilinoquinazoline 15::N-[4-(3-Bromoanilino)-6-quinazolinyl]-2,3-butadienamide::N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}buta-2,3-dienamide

SMILES: Brc1cccc(Nc2ncnc3ccc(NC(=O)C=C=C)cc23)c1

InChI Key: InChIKey=AWZOTLBLGSFFML-UHFFFAOYSA-N

Data: 1 IC50

PDB links: 2 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 4788   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4788 (6-Substituted 4-Anilinoquinazoline 15 | N-[4-(3-Br...) Show SMILES Brc1cccc(Nc2ncnc3ccc(NC(=O)C=C=C)cc23)c1 Show InChI InChI=1S/C18H13BrN4O/c1-2-4-17(24)22-14-7-8-16-15(10-14)18(21-11-20-16)23-13-6-3-5-12(19)9-13/h3-11H,1H2,(H,22,24)(H,20,21,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.4	25
University of Auckland					Assay Description Enzyme assays for IC50 determinations were performed in 96-well filter plates. IC50 is the inhibitor concentration which inhibits 50% of kinase activ...				J Med Chem 44: 429-40 (2001) Article DOI: 10.1021/jm000372i BindingDB Entry DOI: 10.7270/Q2HX19WB
					More data for this Ligand-Target Pair