BindingDB PrimarySearch

BDBM4811 (Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl]-propionic acid::3-(2,4-dimethyl-5-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid::CHEMBL274654::SU6668

SMILES: Cc1[nH]c(\C=C2/C(=O)Nc3ccccc23)c(C)c1CCC(O)=O

InChI Key: InChIKey=NHFDRBXTEDBWCZ-ZROIWOOFSA-N

Data: 22 IC50

PDB links: 2 PDB IDs match this monomer. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 4811
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM4811 ((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	7.5	22
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				J Med Chem 46: 1116-9 (2003) Article DOI: 10.1021/jm0204183 BindingDB Entry DOI: 10.7270/Q2D50K5B
SUGEN, Inc.					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM4811 ((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Nirma University Curated by ChEMBL					Assay Description Inhibition of recombinant aurora B (unknown origin)				Eur J Med Chem 140: 1-19 (2017) Article DOI: 10.1016/j.ejmech.2017.08.045 BindingDB Entry DOI: 10.7270/Q2WD4385
Nirma University Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM4811 ((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				J Med Chem 46: 1116-9 (2003) Article DOI: 10.1021/jm0204183 BindingDB Entry DOI: 10.7270/Q2D50K5B
SUGEN, Inc.					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4811 ((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				J Med Chem 46: 1116-9 (2003) Article DOI: 10.1021/jm0204183 BindingDB Entry DOI: 10.7270/Q2D50K5B
SUGEN, Inc.					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM4811 ((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.43E+3	n/a	n/a	n/a	n/a	7.5	22
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				J Med Chem 42: 5120-30 (1999) Article DOI: 10.1021/jm9904295 BindingDB Entry DOI: 10.7270/Q20Z71GM
SUGEN, Inc.					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4811 ((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				J Med Chem 42: 5120-30 (1999) Article DOI: 10.1021/jm9904295 BindingDB Entry DOI: 10.7270/Q20Z71GM
SUGEN, Inc.					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM4811 ((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				J Med Chem 42: 5120-30 (1999) Article DOI: 10.1021/jm9904295 BindingDB Entry DOI: 10.7270/Q20Z71GM
SUGEN, Inc.					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4811 ((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				J Med Chem 42: 5120-30 (1999) Article DOI: 10.1021/jm9904295 BindingDB Entry DOI: 10.7270/Q20Z71GM
SUGEN, Inc.					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM4811 ((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of Aurora B in the presence of 20uM ATP				Biochem J 408: 297-315 (2007) Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4
University of Dundee Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Aurora-C (Homo sapiens (Human))	BDBM4811 ((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of Aurora C in the presence of 5uM ATP				Biochem J 408: 297-315 (2007) Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4
University of Dundee Curated by ChEMBL					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4811 ((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Mahidol University Curated by ChEMBL					Assay Description Inhibition of rhFGF2-induced cellular proliferation of HUVEC				Bioorg Med Chem Lett 17: 4812-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.058 BindingDB Entry DOI: 10.7270/Q29886Q3
Mahidol University Curated by ChEMBL					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4811 ((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.81E+3	n/a	n/a	n/a	n/a	n/a	n/a
Mahidol University Curated by ChEMBL					Assay Description Inhibition of human FGFR1 expressed in insect cells by HTRF method				Bioorg Med Chem Lett 19: 745-50 (2009) Article DOI: 10.1016/j.bmcl.2008.12.023 BindingDB Entry DOI: 10.7270/Q2028RDT
Mahidol University Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM4811 ((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	680	n/a	n/a	n/a	n/a	n/a	n/a
Mahidol University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin)				Bioorg Med Chem Lett 19: 745-50 (2009) Article DOI: 10.1016/j.bmcl.2008.12.023 BindingDB Entry DOI: 10.7270/Q2028RDT
Mahidol University Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM4811 ((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Mahidol University Curated by ChEMBL					Assay Description Inhibition of PDGFRbeta (unknown origin)				Bioorg Med Chem Lett 19: 745-50 (2009) Article DOI: 10.1016/j.bmcl.2008.12.023 BindingDB Entry DOI: 10.7270/Q2028RDT
Mahidol University Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4811 ((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Mahidol University Curated by ChEMBL					Assay Description Inhibition of EGFR (unknown origin)				Bioorg Med Chem Lett 19: 745-50 (2009) Article DOI: 10.1016/j.bmcl.2008.12.023 BindingDB Entry DOI: 10.7270/Q2028RDT
Mahidol University Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM4811 ((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.84E+4	n/a	n/a	n/a	n/a	n/a	n/a
GVK Biosciences Pvt. Ltd. Curated by ChEMBL					Assay Description Inhibition of human GST-fused ZAP-70 expressed in Sf9 cells				Eur J Med Chem 44: 4793-800 (2009) Article DOI: 10.1016/j.ejmech.2009.07.018 BindingDB Entry DOI: 10.7270/Q25X290Z
GVK Biosciences Pvt. Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM4811 ((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of PDGF-stimulated PDGFRbeta phosphorylation expressed in mouse NIH/3T3 cells by chemiluminescence assay				Bioorg Med Chem 18: 3575-87 (2010) Article DOI: 10.1016/j.bmc.2010.03.052 BindingDB Entry DOI: 10.7270/Q2V69JRB
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM4811 ((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 phosphorylation in HUVEC by chemiluminescence assay				Bioorg Med Chem 18: 3575-87 (2010) Article DOI: 10.1016/j.bmc.2010.03.052 BindingDB Entry DOI: 10.7270/Q2V69JRB
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM4811 ((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	135	n/a	n/a	n/a	n/a	n/a	n/a
Exelixis Curated by ChEMBL					Assay Description Inhibition of N-terminal GST-tagged KDR after 4 hrs by luciferase-luciferin coupled chemiluminescence assay				Bioorg Med Chem Lett 22: 4979-85 (2012) Article DOI: 10.1016/j.bmcl.2012.06.029 BindingDB Entry DOI: 10.7270/Q2XG9SD4
Exelixis Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM4811 ((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Exelixis Curated by ChEMBL					Assay Description Inhibition of N-terminal GST-tagged Flt1 using poly(Glu,Tyr) as substrate after 60 mins by alphascreen assay				Bioorg Med Chem Lett 22: 4979-85 (2012) Article DOI: 10.1016/j.bmcl.2012.06.029 BindingDB Entry DOI: 10.7270/Q2XG9SD4
Exelixis Curated by ChEMBL					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4811 ((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
Exelixis Curated by ChEMBL					Assay Description Inhibition of N-terminal GST-tagged FGFR1 using poly(Glu,Tyr) as substrate after 30 mins by alphascreen assay				Bioorg Med Chem Lett 22: 4979-85 (2012) Article DOI: 10.1016/j.bmcl.2012.06.029 BindingDB Entry DOI: 10.7270/Q2XG9SD4
Exelixis Curated by ChEMBL					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4811 ((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	7.5	22
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				J Med Chem 46: 1116-9 (2003) Article DOI: 10.1021/jm0204183 BindingDB Entry DOI: 10.7270/Q2D50K5B
SUGEN, Inc.					More data for this Ligand-Target Pair