BDBM4823 1-{2-amino-6-phenylpyrido[2,3-d]pyrimidin-7-yl}-3-tert-butylurea::CHEMBL76599::PD089828 analog 4

SMILES: CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1ccccc1

InChI Key: InChIKey=YJOFXQWQYIOWNT-UHFFFAOYSA-N

Data: 7 IC50

PDB links: 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 4823   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM4823 (1-{2-amino-6-phenylpyrido[2,3-d]pyrimidin-7-yl}-3-...) Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1ccccc1 Show InChI InChI=1S/C18H20N6O/c1-18(2,3)24-17(25)23-15-13(11-7-5-4-6-8-11)9-12-10-20-16(19)22-14(12)21-15/h4-10H,1-3H3,(H4,19,20,21,22,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	1.32E+4	n/a	n/a	n/a	n/a	7.4	25
Parke-Davis Pharmaceutical Research					Assay Description The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...				Bioorg Med Chem Lett 7: 2415-20 (1997) Article DOI: 10.1074/jbc.M606873200 BindingDB Entry DOI: 10.7270/Q28C9TF2
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4823 (1-{2-amino-6-phenylpyrido[2,3-d]pyrimidin-7-yl}-3-...) Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1ccccc1 Show InChI InChI=1S/C18H20N6O/c1-18(2,3)24-17(25)23-15-13(11-7-5-4-6-8-11)9-12-10-20-16(19)22-14(12)21-15/h4-10H,1-3H3,(H4,19,20,21,22,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...				Bioorg Med Chem Lett 7: 2415-20 (1997) Article DOI: 10.1074/jbc.M606873200 BindingDB Entry DOI: 10.7270/Q28C9TF2
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4823 (1-{2-amino-6-phenylpyrido[2,3-d]pyrimidin-7-yl}-3-...) Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1ccccc1 Show InChI InChI=1S/C18H20N6O/c1-18(2,3)24-17(25)23-15-13(11-7-5-4-6-8-11)9-12-10-20-16(19)22-14(12)21-15/h4-10H,1-3H3,(H4,19,20,21,22,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	1.93E+4	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...				Bioorg Med Chem Lett 7: 2415-20 (1997) Article DOI: 10.1074/jbc.M606873200 BindingDB Entry DOI: 10.7270/Q28C9TF2
					More data for this Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM4823 (1-{2-amino-6-phenylpyrido[2,3-d]pyrimidin-7-yl}-3-...) Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1ccccc1 Show InChI InChI=1S/C18H20N6O/c1-18(2,3)24-17(25)23-15-13(11-7-5-4-6-8-11)9-12-10-20-16(19)22-14(12)21-15/h4-10H,1-3H3,(H4,19,20,21,22,23,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	1.32E+4	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description Inhibitory activity against platelet-derived growth factor receptor				Bioorg Med Chem Lett 7: 2415-20 (1997) Article DOI: 10.1074/jbc.M606873200 BindingDB Entry DOI: 10.7270/Q28C9TF2
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4823 (1-{2-amino-6-phenylpyrido[2,3-d]pyrimidin-7-yl}-3-...) Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1ccccc1 Show InChI InChI=1S/C18H20N6O/c1-18(2,3)24-17(25)23-15-13(11-7-5-4-6-8-11)9-12-10-20-16(19)22-14(12)21-15/h4-10H,1-3H3,(H4,19,20,21,22,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.53E+3	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research Curated by ChEMBL					Assay Description Inhibition of epidermal growth factor receptor (EGFr) tyrosine kinase				J Med Chem 40: 2296-303 (1997) Article DOI: 10.1021/jm970367n BindingDB Entry DOI: 10.7270/Q2Z31XRR
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4823 (1-{2-amino-6-phenylpyrido[2,3-d]pyrimidin-7-yl}-3-...) Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1ccccc1 Show InChI InChI=1S/C18H20N6O/c1-18(2,3)24-17(25)23-15-13(11-7-5-4-6-8-11)9-12-10-20-16(19)22-14(12)21-15/h4-10H,1-3H3,(H4,19,20,21,22,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research Curated by ChEMBL					Assay Description Inhibition of C-src tyrosine kinase				J Med Chem 40: 2296-303 (1997) Article DOI: 10.1021/jm970367n BindingDB Entry DOI: 10.7270/Q2Z31XRR
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM4823 (1-{2-amino-6-phenylpyrido[2,3-d]pyrimidin-7-yl}-3-...) Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1ccccc1 Show InChI InChI=1S/C18H20N6O/c1-18(2,3)24-17(25)23-15-13(11-7-5-4-6-8-11)9-12-10-20-16(19)22-14(12)21-15/h4-10H,1-3H3,(H4,19,20,21,22,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research Curated by ChEMBL					Assay Description Inhibition of insulin receptor (InsR) tyrosine kinase				J Med Chem 40: 2296-303 (1997) Article DOI: 10.1021/jm970367n BindingDB Entry DOI: 10.7270/Q2Z31XRR
					More data for this Ligand-Target Pair